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Gene entry

WT1

WT1 transcription factor

Chromosome
11
Cytoband
11p13
Variants (rsID)
41

WT1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 11 (region 11p13). Its official name is “WT1 transcription factor”. The reference table lists 41 variants (rsID) for this gene.

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Clinically classified variants

34 reference-table entries with clinical significance.

  • rs16754Benignsingle nucleotide variantNephrotic syndrome, type 4|Meacham syndrome|Wilms tumor 1|Drash syndrome|Frasier syndrome|Nephrotic syndrome, type 4|Wilms tumor 1|Drash syndrome|Frasier syndrome|Wilms tumor 1|11p partial monosomy syndrome|Drash syndrome|Frasier syndrome
  • rs555140661Benignsingle nucleotide variantMeacham syndrome|Nephrotic syndrome, type 4|Wilms tumor 1|Wilms tumor 1|11p partial monosomy syndrome|Drash syndrome|Frasier syndrome|Hereditary cancer-predisposing syndrome
  • rs142059681Conflicting interpretationssingle nucleotide variantWilms tumor 1|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Frasier syndrome|Hereditary cancer-predisposing syndrome
  • rs147241955Conflicting interpretationssingle nucleotide variantWilms tumor 1|11p partial monosomy syndrome|Drash syndrome|Frasier syndrome|Meacham syndrome|Wilms tumor 1|Nephrotic syndrome, type 4
  • rs372418954Conflicting interpretationssingle nucleotide variantDrash syndrome|Frasier syndrome|Wilms tumor 1|11p partial monosomy syndrome|Wilms tumor 1|Drash syndrome|Frasier syndrome|Hereditary cancer-predisposing syndrome
  • rs527655625Conflicting interpretationssingle nucleotide variantWilms tumor 1|11p partial monosomy syndrome|Drash syndrome|Frasier syndrome
  • rs771681406Conflicting interpretationssingle nucleotide variantWilms tumor 1|Nephrotic syndrome, type 4|Meacham syndrome|Drash syndrome|Frasier syndrome|Wilms tumor 1|11p partial monosomy syndrome|Hereditary cancer-predisposing syndrome
  • rs776209354Conflicting interpretationssingle nucleotide variantMeacham syndrome|Wilms tumor 1|Nephrotic syndrome, type 4|Drash syndrome|Frasier syndrome|Wilms tumor 1|11p partial monosomy syndrome|Hereditary cancer-predisposing syndrome
  • rs1057519745Likely pathogenicInsertionAcute myeloid leukemia
  • rs121907902Likely pathogenicsingle nucleotide variantDrash syndrome|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Frasier syndrome
  • rs1349302999Likely pathogenicsingle nucleotide variant
  • rs267602852Likely pathogenicsingle nucleotide variantFrasier syndrome
  • rs28942089Likely pathogenicsingle nucleotide variantDrash syndrome|Nephrotic syndrome, type 4
  • rs869025561Likely pathogenicsingle nucleotide variantFamilial idiopathic steroid-resistant nephrotic syndrome
  • rs121907900Pathogenicsingle nucleotide variantDrash syndrome|Nephrotic syndrome, type 4|Meacham syndrome|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Frasier syndrome|Steroid-resistant nephrotic syndrome|Nephrotic range proteinuria|Wilms tumor 1
  • rs121907901Pathogenicsingle nucleotide variantDrash syndrome|Nephrotic syndrome, type 4|Drash syndrome|Wilms tumor 1|Frasier syndrome|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Frasier syndrome|Nephrotic syndrome, type 4
  • rs121907903Pathogenicsingle nucleotide variantDrash syndrome
  • rs121907904Pathogenicsingle nucleotide variantDrash syndrome
  • rs121907905Pathogenicsingle nucleotide variantDrash syndrome
  • rs121907906Pathogenicsingle nucleotide variantDrash syndrome|Wilms tumor 1|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Frasier syndrome|8 conditions
  • rs121907907Pathogenicsingle nucleotide variantDrash syndrome
  • rs121907908Pathogenicsingle nucleotide variantMesothelioma
  • rs121907909Pathogenicsingle nucleotide variantWilms tumor 1|Frasier syndrome|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Frasier syndrome
  • rs121907910Pathogenicsingle nucleotide variantMeacham syndrome
  • rs121907911Pathogenicsingle nucleotide variantWilms tumor 1
  • rs1423753702Pathogenicsingle nucleotide variantWilms tumor 1|Drash syndrome|Frasier syndrome|Wilms tumor 1|11p partial monosomy syndrome|Drash syndrome|See cases
  • rs28941777Pathogenicsingle nucleotide variantNephrotic syndrome, type 4
  • rs28941778Pathogenicsingle nucleotide variantDrash syndrome|Nephrotic syndrome, type 4
  • rs28941779Pathogenicsingle nucleotide variantFrasier syndrome
  • rs587776573PathogenicDeletionWilms tumor 1
  • rs587776574PathogenicDeletionWilms tumor 1
  • rs587776575Pathogenicsingle nucleotide variantFrasier syndrome
  • rs587776576Pathogenicsingle nucleotide variantDrash syndrome|Frasier syndrome|Familial idiopathic steroid-resistant nephrotic syndrome|Nephrotic syndrome, type 4|Frasier syndrome|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Wilms tumor 1
  • rs587776577Pathogenicsingle nucleotide variantFrasier syndrome|Nephrotic syndrome, type 4|Familial idiopathic steroid-resistant nephrotic syndrome|Nephrotic range proteinuria|Frasier syndrome|Drash syndrome|Wilms tumor 1|11p partial monosomy syndrome|Wilms tumor 1

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.