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Gene entry

SDHB

succinate dehydrogenase complex iron sulfur subunit B

Chromosome
1
Cytoband
1p36.13
Variants (rsID)
72

SDHB is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 1 (region 1p36.13). Its official name is “succinate dehydrogenase complex iron sulfur subunit B”. The reference table lists 72 variants (rsID) for this gene.

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Clinically classified variants

68 reference-table entries with clinical significance.

  • rs111430410Benignsingle nucleotide variantRenal cell carcinoma, papillary, 1|Gastrointestinal stromal tumor|Paragangliomas 4|Pheochromocytoma|Hereditary pheochromocytoma-paraganglioma|Hereditary cancer-predisposing syndrome|Paragangliomas 4|Gastrointestinal stromal tumor|Paraganglioma|Pheochromocytoma|Pheochromocytoma|Paraganglioma
  • rs34916635Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Carney-Stratakis syndrome|Hereditary pheochromocytoma-paraganglioma|Gastrointestinal stromal tumor|Cowden syndrome 1|Carney-Stratakis syndrome|Paragangliomas 4|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Pheochromocytoma
  • rs1228560456Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma
  • rs150542357Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 4|Pheochromocytoma|Gastrointestinal stromal tumor
  • rs190139590Conflicting interpretationssingle nucleotide variantParagangliomas 4|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Gastrointestinal stromal tumor|Hereditary cancer-predisposing syndrome
  • rs201585157Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma
  • rs202101384Conflicting interpretationssingle nucleotide variantMitochondrial complex 2 deficiency, nuclear type 4|Paragangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma|Hereditary cancer-predisposing syndrome|Mitochondrial complex II deficiency, nuclear type 1
  • rs33927012Conflicting interpretationssingle nucleotide variantCowden syndrome|Hereditary cancer-predisposing syndrome|Gastrointestinal stromal tumor|Pheochromocytoma|Paragangliomas 4|Paragangliomas 4|Hereditary pheochromocytoma-paraganglioma|Gastrointestinal stromal tumor|Carney-Stratakis syndrome|Malignant tumor of breast
  • rs397516834Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome
  • rs587782904Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs727503415Conflicting interpretationssingle nucleotide variantHereditary pheochromocytoma-paraganglioma|Hereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs876658540Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1064794269Likely pathogenicsingle nucleotide variant
  • rs1480267715Likely pathogenicDeletionHereditary pheochromocytoma-paraganglioma
  • rs786201085Likely pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs864321636Likely pathogenicsingle nucleotide variantPheochromocytoma
  • rs864321637Likely pathogenicsingle nucleotide variantPheochromocytoma
  • rs864321638Likely pathogenicsingle nucleotide variantPheochromocytoma
  • rs864321639Likely pathogenicDeletionPheochromocytoma
  • rs876659329Likely pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome
  • rs876659330Likely pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome
  • rs878854574Likely pathogenicsingle nucleotide variantParagangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma
  • rs878854576Likely pathogenicsingle nucleotide variantParagangliomas 4|Hereditary cancer-predisposing syndrome|Paragangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma
  • rs1060503751PathogenicMicrosatellitePheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary pheochromocytoma-paraganglioma
  • rs1060503752PathogenicDeletionPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1060503753Pathogenicsingle nucleotide variantPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1060503757PathogenicDeletionPheochromocytoma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary cancer-predisposing syndrome|Cowden syndrome|Gastrointestinal stromal tumor|SDHB-Related Disorders
  • rs1060503759Pathogenicsingle nucleotide variantPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1060503762Pathogenicsingle nucleotide variantPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1060503763Pathogenicsingle nucleotide variantPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1060503764PathogenicDuplicationPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary cancer-predisposing syndrome
  • rs1064794270Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Pheochromocytoma|Paragangliomas 4|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs1209914140PathogenicInsertionParagangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma
  • rs200245469Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Paragangliomas 4
  • rs267607032Pathogenicsingle nucleotide variantParagangliomas 4|Hereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs34309090PathogenicDuplicationHereditary pheochromocytoma-paraganglioma
  • rs587781270Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary pheochromocytoma-paraganglioma|Paragangliomas 4
  • rs587782243Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary pheochromocytoma-paraganglioma
  • rs587782617PathogenicDeletionHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs727504457Pathogenicsingle nucleotide variantHereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary cancer-predisposing syndrome
  • rs74315367Pathogenicsingle nucleotide variantParagangliomas 4|Hereditary pheochromocytoma-paraganglioma|Hereditary cancer-predisposing syndrome|Gastrointestinal stromal tumor|Pheochromocytoma|Paragangliomas 4
  • rs74315368Pathogenicsingle nucleotide variantPheochromocytoma|Paragangliomas 4|Gastrointestinal stromal tumor|Hereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Paragangliomas 4|Gastrointestinal stromal tumor|SDHB-Related Disorders
  • rs74315370Pathogenicsingle nucleotide variantPheochromocytoma|Hereditary cancer-predisposing syndrome|Gastrointestinal stromal tumor|Pheochromocytoma|Paragangliomas 4
  • rs74315371Pathogenicsingle nucleotide variantPheochromocytoma
  • rs74315372Pathogenicsingle nucleotide variantParagangliomas 4|Hereditary cancer-predisposing syndrome|Gastrointestinal stromal tumor|Pheochromocytoma|Paragangliomas 4
  • rs747198089PathogenicDeletionHereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs751000085Pathogenicsingle nucleotide variantHereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Paragangliomas 4
  • rs786201063Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Paragangliomas 4
  • rs786202100PathogenicDeletionHereditary cancer-predisposing syndrome|Paragangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma|Paragangliomas 4|Pheochromocytoma
  • rs786202732Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs786203251Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 4|Pheochromocytoma|Gastrointestinal stromal tumor
  • rs786203800Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs794728947PathogenicDuplicationHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs794728948PathogenicDuplication
  • rs794728950PathogenicDeletionHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs876658367Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 4|Hereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs876658451Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary pheochromocytoma-paraganglioma|Paragangliomas 4|Pheochromocytoma|Gastrointestinal stromal tumor
  • rs876658461Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 4|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Pheochromocytoma|Carney-Stratakis syndrome|Paragangliomas 4|Hereditary pheochromocytoma-paraganglioma
  • rs876659491PathogenicDeletionHereditary cancer-predisposing syndrome
  • rs876660368PathogenicDeletionHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs876660642PathogenicDeletionHereditary cancer-predisposing syndrome|Pheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4
  • rs878854572PathogenicDeletionParagangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma
  • rs878854575Pathogenicsingle nucleotide variantParagangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma|Hereditary pheochromocytoma-paraganglioma
  • rs121917755Uncertain significancesingle nucleotide variantPheochromocytoma|Inborn genetic diseases|Pheochromocytoma|Paragangliomas 4|Gastrointestinal stromal tumor
  • rs1278834014Uncertain significancesingle nucleotide variantHereditary pheochromocytoma-paraganglioma|Pheochromocytoma|Paragangliomas 4|Gastrointestinal stromal tumor
  • rs146800605Uncertain significancesingle nucleotide variantPheochromocytoma|Gastrointestinal stromal tumor|Paragangliomas 4|Hereditary cancer-predisposing syndrome
  • rs201082445Uncertain significancesingle nucleotide variantParagangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma|Hereditary cancer-predisposing syndrome
  • rs202014362Uncertain significancesingle nucleotide variantParagangliomas 4|Gastrointestinal stromal tumor|Pheochromocytoma|Cowden syndrome

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.