Gene entry
NRAS
NRAS proto-oncogene, GTPase
- Chromosome
- 1
- Cytoband
- 1p13.2
- Variants (rsID)
- 11
NRAS is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 1 (region 1p13.2). Its official name is “NRAS proto-oncogene, GTPase”. The reference table lists 11 variants (rsID) for this gene.
Clinically classified variants
8 reference-table entries with clinical significance.
- rs142739534Benignsingle nucleotide variantNoonan syndrome 6|RASopathy
- rs14804Benignsingle nucleotide variantNoonan syndrome 6
- rs61758211Benignsingle nucleotide variantNoonan syndrome 6
- rs121913255Conflicting interpretationssingle nucleotide variantGlioblastoma|Acute myeloid leukemia|Hepatocellular carcinoma|Thyroid tumor|Nasopharyngeal neoplasm|Multiple myeloma|Adrenal cortex carcinoma|Malignant melanoma of skin|B-cell chronic lymphocytic leukemia|Ovarian serous cystadenocarcinoma|Malignant neoplasm of body of uterus|Transitional cell carcinoma of the bladder|Neoplasm of the large intestine|Gastric adenocarcinoma|Renal cell carcinoma, papillary, 1|Lung adenocarcinoma|Melanoma|Neoplasm of brain|Noonan syndrome and Noonan-related syndrome
- rs374061873Conflicting interpretationssingle nucleotide variantNoonan syndrome 6|RASopathy|Noonan syndrome
- rs11554290Pathogenicsingle nucleotide variantThyroid cancer, nonmedullary, 2|Epidermal nevus|Non-small cell lung carcinoma|Large congenital melanocytic nevus|Neurocutaneous melanocytosis|Linear nevus sebaceous syndrome|Renal cell carcinoma, papillary, 1|B-cell chronic lymphocytic leukemia|Melanoma|Neoplasm of brain|Lung adenocarcinoma|Adrenal cortex carcinoma|Ovarian serous cystadenocarcinoma|Malignant melanoma of skin|Nasopharyngeal neoplasm|Hepatocellular carcinoma|Multiple myeloma|Gastric adenocarcinoma|Neoplasm of the large intestine|Glioblastoma|Acute myeloid leukemia|Transitional cell carcinoma of the bladder|Malignant neoplasm of body of uterus
- rs267606920Pathogenicsingle nucleotide variantNoonan syndrome 6|Noonan syndrome 1|RASopathy
- rs267606921Pathogenicsingle nucleotide variantNoonan syndrome 6|Noonan syndrome|Noonan syndrome 1|RASopathy
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.