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Gene entry

KRAS

KRas proto-oncogene, GTPase

Chromosome
12
Cytoband
12p12.1
Variants (rsID)
29

KRAS is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 12 (region 12p12.1). Its official name is “KRas proto-oncogene, GTPase”. The reference table lists 29 variants (rsID) for this gene.

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Clinically classified variants

23 reference-table entries with clinical significance.

  • rs727503111Benignsingle nucleotide variantNoonan syndrome|RASopathy
  • rs9266Benignsingle nucleotide variantNoonan syndrome|Noonan syndrome and Noonan-related syndrome
  • rs112445441Conflicting interpretationssingle nucleotide variantBreast adenocarcinoma|Non-small cell lung carcinoma|Juvenile myelomonocytic leukemia|Autoimmune lymphoproliferative syndrome type 4|Neoplasm of the large intestine|Acute myeloid leukemia|Thyroid tumor|Neoplasm of ovary|OCULOECTODERMAL SYNDROME, SOMATIC|Inborn genetic diseases|Nevus sebaceous|Noonan syndrome and Noonan-related syndrome|Encephalocraniocutaneous lipomatosis|RASopathy
  • rs121913527Conflicting interpretationssingle nucleotide variantRASopathy
  • rs200229810Conflicting interpretationssingle nucleotide variantNoonan syndrome|RASopathy
  • rs201170656Conflicting interpretationssingle nucleotide variant
  • rs370920665Conflicting interpretationssingle nucleotide variantNoonan syndrome|RASopathy
  • rs373169526Conflicting interpretationssingle nucleotide variantCardio-facio-cutaneous syndrome
  • rs397517476Likely benignsingle nucleotide variant
  • rs61763587Likely benignsingle nucleotide variant
  • rs104894360Pathogenicsingle nucleotide variantNoonan syndrome 3|Cardiofaciocutaneous syndrome 2|RASopathy|Noonan syndrome|11 conditions|Cardio-facio-cutaneous syndrome|Noonan syndrome|Inborn genetic diseases
  • rs104894361Pathogenicsingle nucleotide variantCardiofaciocutaneous syndrome 2|Noonan syndrome|Inborn genetic diseases
  • rs104894362Pathogenicsingle nucleotide variantCardiofaciocutaneous syndrome 2|RASopathy
  • rs104894364Pathogenicsingle nucleotide variantNoonan syndrome 3|Noonan syndrome|RASopathy
  • rs104894365Pathogenicsingle nucleotide variantNoonan syndrome 3|Endometrial carcinoma|RASopathy|Noonan syndrome|Noonan syndrome|Cardio-facio-cutaneous syndrome|Inborn genetic diseases|Noonan syndrome and Noonan-related syndrome
  • rs104894366Pathogenicsingle nucleotide variantCardiofaciocutaneous syndrome 2|Cardio-facio-cutaneous syndrome|Noonan syndrome|Acute myeloid leukemia|Autoimmune lymphoproliferative syndrome type 4|Cardiofaciocutaneous syndrome 2|Noonan syndrome 3|RASopathy
  • rs121913238Pathogenicsingle nucleotide variantNon-small cell lung carcinoma|Thyroid tumor|Neoplasm of the large intestine
  • rs121913528Pathogenicsingle nucleotide variantBladder cancer, transitional cell, somatic|Neoplasm of the large intestine
  • rs121913529Pathogenicsingle nucleotide variantCarcinoma of pancreas|Neoplasm of stomach|Epidermal nevus|Nevus sebaceous|Linear nevus sebaceous syndrome|Juvenile myelomonocytic leukemia|Autoimmune lymphoproliferative syndrome type 4|Non-small cell lung carcinoma|Neoplasm of ovary|Neoplasm of the large intestine|Lung carcinoma|Acute myeloid leukemia|Thyroid tumor|RASopathy|Cerebral arteriovenous malformation|Vascular Tumors Including Pyogenic Granuloma|Primary low grade serous adenocarcinoma of ovary|Capillary malformation-arteriovenous malformation 1|Encephalocraniocutaneous lipomatosis
  • rs17851045Pathogenicsingle nucleotide variantNon-small cell lung carcinoma|Neoplasm of the large intestine|Malignant melanoma of skin|Thyroid tumor|Hepatocellular carcinoma|Squamous cell lung carcinoma|Multiple myeloma|Lung adenocarcinoma|Acute myeloid leukemia|B-cell chronic lymphocytic leukemia|Malignant neoplasm of body of uterus|Transitional cell carcinoma of the bladder|Pancreatic adenocarcinoma|Gastric adenocarcinoma
  • rs193929331Pathogenicsingle nucleotide variantNoonan syndrome 3|RASopathy|Noonan syndrome|Prostate cancer, hereditary, 1
  • rs369501492Uncertain significancesingle nucleotide variantRASopathy
  • rs104886029Not classifiedsingle nucleotide variantFamilial cancer of breast

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.