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Variant (rsID / SNP)

rs17849781

TP53

rs17849781 is a genetic variant (SNP, identifier in the dbSNP catalogue) that the reference table assigns to TP53. Location: chromosome 17, position 7,577,106. Clinical significance in the table: Conflicting interpretations of pathogenicity.

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Reference-table entries

TP53Conflicting interpretations
Clinical significance (as recorded)
Conflicting interpretations of pathogenicity
Variant type
single nucleotide variant
Chromosome / position
17:7577106
Cytoband
17p13.1
HGVS
NM_000546.6(TP53):c.832C>T (p.Pro278Ser)
Allele change
Missense_P146A

Associated conditions / phenotypes

Squamous cell carcinoma of the skin|Squamous cell carcinoma of the head and neck|Malignant melanoma of skin|Lung adenocarcinoma|Neoplasm of brain|Carcinoma of esophagus|Malignant neoplasm of body of uterus|Breast neoplasm|Ovarian serous cystadenocarcinoma|Pancreatic adenocarcinoma|Squamous cell lung carcinoma|Multiple myeloma|Neoplasm of the large intestine|Hereditary cancer-predisposing syndrome|Li-Fraumeni syndrome|Neoplasm of ovary

Public references

Classifications are reproduced unchanged from the reference table. For education only; not a substitute for medical or genetic counselling.