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Gene entry

WFS1

wolframin ER transmembrane glycoprotein

Chromosome
4
Cytoband
4p16.1
Variants (rsID)
64

WFS1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 4 (region 4p16.1). Its official name is “wolframin ER transmembrane glycoprotein”. The reference table lists 64 variants (rsID) for this gene.

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Clinically classified variants

58 reference-table entries with clinical significance.

  • rs1046314Benignsingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6|Sensorineural hearing loss disorder|Diabetes mellitus
  • rs1046317Benignsingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs141328044Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders|Monogenic diabetes
  • rs150936382Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders
  • rs1805069Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders|Monogenic diabetes
  • rs41264699Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders|Monogenic diabetes
  • rs55814513Benignsingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6|Monogenic diabetes
  • rs61735401Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders
  • rs71532874Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|Monogenic diabetes|WFS1-Related Spectrum Disorders
  • rs734312Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders|Wolfram syndrome 1
  • rs112871383Conflicting interpretationssingle nucleotide variantMonogenic diabetes
  • rs113446173Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|Type 2 diabetes mellitus|Wolfram syndrome 1|Cataract 41|Wolfram-like syndrome|Autosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders|Monogenic diabetes|Hearing impairment|Spastic ataxia
  • rs138232538Conflicting interpretationssingle nucleotide variantMonogenic diabetes|WFS1-Related Spectrum Disorders
  • rs140115060Conflicting interpretationssingle nucleotide variant
  • rs141177727Conflicting interpretationssingle nucleotide variant
  • rs141585847Conflicting interpretationssingle nucleotide variantHearing impairment
  • rs145144527Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs146670741Conflicting interpretationssingle nucleotide variantRare genetic deafness|Monogenic diabetes
  • rs147834269Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders|Wolfram syndrome 1
  • rs149013740Conflicting interpretationssingle nucleotide variant
  • rs188848517Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs199910987Conflicting interpretationssingle nucleotide variantWolfram syndrome 1|Monogenic diabetes
  • rs199946797Conflicting interpretationssingle nucleotide variantWolfram syndrome|WFS1-Related Spectrum Disorders|Diabetes mellitus|Wolfram syndrome 1
  • rs200135768Conflicting interpretationssingle nucleotide variantMonogenic diabetes|WFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs201078003Conflicting interpretationssingle nucleotide variant
  • rs28937894Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6
  • rs35031397Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Monogenic diabetes|Wolfram syndrome 1|Autosomal dominant nonsyndromic hearing loss 6
  • rs35932623Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6|Monogenic diabetes|Wolfram syndrome 1
  • rs377539343Conflicting interpretationssingle nucleotide variant
  • rs56002719Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Monogenic diabetes|Autosomal dominant nonsyndromic hearing loss 6|Nonsyndromic genetic hearing loss
  • rs56035336Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs71524349Conflicting interpretationssingle nucleotide variantMonogenic diabetes
  • rs71524353Conflicting interpretationssingle nucleotide variantMonogenic diabetes|WFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs71539657Conflicting interpretationssingle nucleotide variantMonogenic diabetes|WFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6
  • rs71539668Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders
  • rs752100338Conflicting interpretationssingle nucleotide variantWFS1-Related Spectrum Disorders|Nonsyndromic Hearing Loss, Dominant
  • rs772392224Conflicting interpretationssingle nucleotide variant
  • rs369107336Likely benignsingle nucleotide variant
  • rs104893879Pathogenicsingle nucleotide variantWolfram syndrome 1
  • rs104893882Pathogenicsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6
  • rs138682654Pathogenicsingle nucleotide variant
  • rs142668478Pathogenicsingle nucleotide variantRare genetic deafness
  • rs201239579Pathogenicsingle nucleotide variantWolfram-like syndrome
  • rs28937891Pathogenicsingle nucleotide variantWolfram syndrome 1
  • rs28937892Pathogenicsingle nucleotide variantWolfram syndrome 1|Wolfram syndrome 1|Wolfram-like syndrome
  • rs28937893Pathogenicsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|Rare genetic deafness
  • rs71530923Pathogenicsingle nucleotide variantWolfram syndrome 1|Wolfram-like syndrome|Wolfram syndrome 1|Autosomal dominant nonsyndromic hearing loss 6|Type 2 diabetes mellitus|Wolfram-like syndrome|Cataract 41|Wolfram syndrome 1|Autosomal dominant nonsyndromic hearing loss 6|Type 2 diabetes mellitus
  • rs71539673Pathogenicsingle nucleotide variantWolfram-like syndrome
  • rs74315205Pathogenicsingle nucleotide variantWolfram-like syndrome|Autosomal dominant nonsyndromic hearing loss 6|Rare genetic deafness|Wolfram syndrome 1|Nonsyndromic genetic hearing loss
  • rs121912618Uncertain significancesingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders
  • rs181988441Uncertain significancesingle nucleotide variantMonogenic diabetes
  • rs200058166Uncertain significancesingle nucleotide variantWolfram-like syndrome|Wolfram syndrome 1
  • rs201557396Uncertain significancesingle nucleotide variant
  • rs202195756Uncertain significancesingle nucleotide variant
  • rs56393026Uncertain significancesingle nucleotide variantAutistic behavior|Autosomal dominant nonsyndromic hearing loss 6|WFS1-Related Spectrum Disorders
  • rs71526458Uncertain significancesingle nucleotide variantMonogenic diabetes|Type 2 diabetes mellitus
  • rs71532861Uncertain significancesingle nucleotide variantWFS1-Related Spectrum Disorders|Autosomal dominant nonsyndromic hearing loss 6|Spastic ataxia
  • rs71537685Uncertain significancesingle nucleotide variant

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.