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Gene entry

VKORC1

vitamin K epoxide reductase complex subunit 1

Chromosome
16
Cytoband
16p11.2
Variants (rsID)
26

VKORC1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 16 (region 16p11.2). Its official name is “vitamin K epoxide reductase complex subunit 1”. The reference table lists 26 variants (rsID) for this gene.

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Clinically classified variants

14 reference-table entries with clinical significance.

  • rs55894764Benignsingle nucleotide variantVitamin K-dependent clotting factors, combined deficiency of, type 2
  • rs7200749Benignsingle nucleotide variantVitamin K-dependent clotting factors, combined deficiency of, type 2
  • rs61742245Conflicting interpretationssingle nucleotide variantWarfarin response|Vitamin K-dependent clotting factors, combined deficiency of, type 2|Thrombus
  • rs104894542Drug responsesingle nucleotide variantWarfarin response
  • rs2359612Drug responsesingle nucleotide variantwarfarin response - Dosage
  • rs2884737Drug responsesingle nucleotide variantwarfarin response - Dosage
  • rs7294Drug responsesingle nucleotide variantwarfarin response - Dosage|Vitamin K-dependent clotting factors, combined deficiency of, type 2
  • rs8050894Drug responsesingle nucleotide variantwarfarin response - Dosage
  • rs9923231Drug responsesingle nucleotide variantWarfarin response|phenprocoumon response - Dosage|warfarin response - Toxicity|phenprocoumon response - Toxicity
  • rs9934438Drug responsesingle nucleotide variantWarfarin response|warfarin response - Dosage|acenocoumarol response - Dosage|Vitamin K-Dependent Clotting Factors|phenprocoumon response - Dosage
  • rs104894539Pathogenicsingle nucleotide variantWarfarin response
  • rs104894540Pathogenicsingle nucleotide variantWarfarin response
  • rs104894541Pathogenicsingle nucleotide variantWarfarin response
  • rs200133418Uncertain significancesingle nucleotide variantVitamin K-dependent clotting factors, combined deficiency of, type 2

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.