Gene entry
TPM1
tropomyosin 1
- Chromosome
- 15
- Cytoband
- 15q22.2
- Variants (rsID)
- 63
TPM1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 15 (region 15q22.2). Its official name is “tropomyosin 1”. The reference table lists 63 variants (rsID) for this gene.
Clinically classified variants
49 reference-table entries with clinical significance.
- rs1071646Benignsingle nucleotide variantCardiovascular phenotype|Dilated cardiomyopathy 1Y|Hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 1|Cardiomyopathy|Hypertrophic cardiomyopathy 3
- rs11558747Benignsingle nucleotide variantCardiovascular phenotype|Dilated cardiomyopathy 1Y|Hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 3|Cardiomyopathy
- rs200484871Benignsingle nucleotide variantHypertrophic cardiomyopathy|Cardiomyopathy
- rs104894505Conflicting interpretationssingle nucleotide variantDilated cardiomyopathy 1Y|Hypertrophic cardiomyopathy
- rs144045691Conflicting interpretationssingle nucleotide variantPrimary familial hypertrophic cardiomyopathy|Cardiomyopathy
- rs199476306Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy|Cardiovascular phenotype
- rs199476312Conflicting interpretationssingle nucleotide variantPrimary familial hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy
- rs199476321Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy|Primary familial hypertrophic cardiomyopathy|Cardiovascular phenotype|Dilated cardiomyopathy 1Y
- rs200173919Conflicting interpretationssingle nucleotide variantDilated cardiomyopathy 1Y|Hypertrophic cardiomyopathy|Cardiomyopathy|Hypertrophic cardiomyopathy 3
- rs202228866Conflicting interpretationssingle nucleotide variantCatecholaminergic polymorphic ventricular tachycardia 1|Hypertrophic cardiomyopathy|Cardiovascular phenotype|Cardiomyopathy|Hypertrophic cardiomyopathy 3|Dilated cardiomyopathy 1Y
- rs397516365Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Dilated cardiomyopathy 1Y|Hypertrophic cardiomyopathy|Cardiomyopathy|Hypertrophic cardiomyopathy 3
- rs397516372Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy
- rs397516395Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy|Dilated cardiomyopathy 1Y|Cardiovascular phenotype|Cardiomyopathy|Hypertrophic cardiomyopathy 3|Primary dilated cardiomyopathy
- rs532254032Conflicting interpretationssingle nucleotide variantDilated cardiomyopathy 1Y|Hypertrophic cardiomyopathy 3|Cardiomyopathy|Hypertrophic cardiomyopathy
- rs730881128Conflicting interpretationssingle nucleotide variantCardiomyopathy
- rs730881160Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy
- rs375043184Likely benignsingle nucleotide variantHypertrophic cardiomyopathy|Cardiomyopathy
- rs730881126Likely benignsingle nucleotide variant
- rs759150466Likely benignsingle nucleotide variantHypertrophic cardiomyopathy
- rs1064793284Likely pathogenicsingle nucleotide variant
- rs199476310Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy|Hypertrophic cardiomyopathy
- rs397516363Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
- rs397516364Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
- rs397516370Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
- rs397516371Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
- rs727503518Likely pathogenicsingle nucleotide variantHypertrophic cardiomyopathy
- rs727504264Likely pathogenicsingle nucleotide variantHypertrophic cardiomyopathy
- rs727504389Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
- rs730881134Likely pathogenicsingle nucleotide variant
- rs730881140Likely pathogenicsingle nucleotide variant
- rs730881159Likely pathogenicsingle nucleotide variant
- rs754664923Likely pathogenicsingle nucleotide variantCardiovascular phenotype
- rs876657662Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
- rs879253758Likely pathogenicsingle nucleotide variantEffort-induced polymorphic ventricular tachycardia
- rs104894501Pathogenicsingle nucleotide variantDilated cardiomyopathy 1Y
- rs104894503Pathogenicsingle nucleotide variantHypertrophic cardiomyopathy 3|Primary familial hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy|Cardiovascular phenotype|Dilated cardiomyopathy 1Y|Cardiomyopathy
- rs104894504Pathogenicsingle nucleotide variantHypertrophic cardiomyopathy 3|Hypertrophic cardiomyopathy|Cardiovascular phenotype
- rs199476311Pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy|Dilated cardiomyopathy 1Y
- rs199476315Pathogenicsingle nucleotide variantLeft ventricular noncompaction 9|Primary familial hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 3
- rs199476316Pathogenicsingle nucleotide variantCardiomyopathy|Primary familial hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy|Cardiovascular phenotype|Dilated cardiomyopathy 1Y
- rs199476317Pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy|Hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 3|Dilated cardiomyopathy 1Y
- rs199476319Pathogenicsingle nucleotide variantLeft ventricular noncompaction 9
- rs730881136Pathogenicsingle nucleotide variant
- rs730881157Pathogenicsingle nucleotide variant
- rs193922410Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
- rs397516390Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
- rs397516486Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
- rs727504354Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
- rs886039444Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.