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Gene entry

TNNI3

troponin I3, cardiac type

Chromosome
19
Cytoband
19q13.42
Variants (rsID)
53

TNNI3 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 19 (region 19q13.42). Its official name is “troponin I3, cardiac type”. The reference table lists 53 variants (rsID) for this gene.

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Clinically classified variants

47 reference-table entries with clinical significance.

  • rs139150276Benignsingle nucleotide variantHypertrophic cardiomyopathy
  • rs201240150Benignsingle nucleotide variantHypertrophic cardiomyopathy|Cardiomyopathy
  • rs77615401Benignsingle nucleotide variantHypertrophic cardiomyopathy 7|Hypertrophic cardiomyopathy|Cardiomyopathy|Cardiovascular phenotype|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Familial restrictive cardiomyopathy|Dilated Cardiomyopathy, Recessive|Cardiomyopathy|Amyloidogenic transthyretin amyloidosis|Dilated cardiomyopathy 2A|Cardiomyopathy, familial restrictive, 1
  • rs9636153Benignsingle nucleotide variantNemaline Myopathy, Recessive|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Hypertrophic cardiomyopathy|Familial restrictive cardiomyopathy|Dilated Cardiomyopathy, Recessive|Nemaline myopathy 5
  • rs1057521530Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy
  • rs193922409Conflicting interpretationssingle nucleotide variant
  • rs367809676Conflicting interpretationssingle nucleotide variantDilated cardiomyopathy 2A|Hypertrophic cardiomyopathy 7|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Cardiomyopathy, familial restrictive, 1|Hypertrophic cardiomyopathy
  • rs3729712Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 1|Dilated cardiomyopathy 2A|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Cardiomyopathy|Cardiomyopathy, familial restrictive, 1|Hypertrophic cardiomyopathy 7
  • rs375447438Conflicting interpretationssingle nucleotide variantDilated cardiomyopathy 2A|Hypertrophic cardiomyopathy 7|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Cardiomyopathy, familial restrictive, 1
  • rs377258542Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy|Dilated cardiomyopathy 2A|Cardiomyopathy, familial restrictive, 1|Hypertrophic cardiomyopathy 7|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Cardiomyopathy
  • rs730881071Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy|Cardiomyopathy
  • rs730881085Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy
  • rs730881091Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy 7|Hypertrophic cardiomyopathy
  • rs75491697Conflicting interpretationssingle nucleotide variantHypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 7|Dilated cardiomyopathy 2A|Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome|Cardiomyopathy, familial restrictive, 1|Cardiomyopathy
  • rs397516346Likely benignsingle nucleotide variantHypertrophic cardiomyopathy|Cardiomyopathy
  • rs747756509Likely benignsingle nucleotide variantHypertrophic cardiomyopathy|Cardiomyopathy
  • rs267607128Likely pathogenicsingle nucleotide variantHypertrophic cardiomyopathy 7|Hypertrophic cardiomyopathy
  • rs397516340Likely pathogenicsingle nucleotide variantHypertrophic cardiomyopathy
  • rs397516341Likely pathogenicsingle nucleotide variantHypertrophic cardiomyopathy
  • rs397516352Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
  • rs397516356Likely pathogenicsingle nucleotide variantPrimary dilated cardiomyopathy
  • rs727503500Likely pathogenicsingle nucleotide variantHypertrophic cardiomyopathy
  • rs730881076Likely pathogenicsingle nucleotide variant
  • rs730881079Likely pathogenicsingle nucleotide variant
  • rs730881081Likely pathogenicsingle nucleotide variant
  • rs730881090Likely pathogenicsingle nucleotide variant
  • rs104894724Pathogenicsingle nucleotide variantHypertrophic cardiomyopathy 7|Cardiovascular phenotype|Hypertrophic cardiomyopathy|Cardiomyopathy
  • rs104894725Pathogenicsingle nucleotide variantHypertrophic cardiomyopathy 7
  • rs104894727Pathogenicsingle nucleotide variantHypertrophic cardiomyopathy 7|Primary familial hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy|Cardiomyopathy
  • rs104894728Pathogenicsingle nucleotide variantCardiomyopathy, familial restrictive, 1|Hypertrophic cardiomyopathy 7
  • rs104894729Pathogenicsingle nucleotide variantCardiomyopathy, familial restrictive, 1|Restrictive cardiomyopathy|Hypertrophic cardiomyopathy|Primary familial hypertrophic cardiomyopathy|Cardiovascular phenotype|Hypertrophic cardiomyopathy|Restrictive cardiomyopathy
  • rs104894730Pathogenicsingle nucleotide variantCardiomyopathy, familial restrictive, 1|Hypertrophic cardiomyopathy 7
  • rs121917760Pathogenicsingle nucleotide variantCardiomyopathy, familial restrictive, 1
  • rs267607129Pathogenicsingle nucleotide variantDilated cardiomyopathy 1FF
  • rs267607130Pathogenicsingle nucleotide variantDilated cardiomyopathy 1FF
  • rs368861241Pathogenicsingle nucleotide variantPrimary familial hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy|Hypertrophic cardiomyopathy 7|Cardiovascular phenotype|Cardiomyopathy
  • rs727503499Pathogenicsingle nucleotide variantRestrictive cardiomyopathy|Hypertrophic cardiomyopathy
  • rs730880231Pathogenicsingle nucleotide variantRestrictive cardiomyopathy
  • rs730881077Pathogenicsingle nucleotide variant
  • rs730881078Pathogenicsingle nucleotide variant
  • rs876661394Pathogenicsingle nucleotide variantCardiovascular phenotype
  • rs121917761Uncertain significancesingle nucleotide variantCardiomyopathy, familial restrictive, 1|Hypertrophic cardiomyopathy
  • rs397516358Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
  • rs727504365Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
  • rs730881072Uncertain significancesingle nucleotide variantHypertrophic cardiomyopathy
  • rs730881089Uncertain significancesingle nucleotide variant
  • rs759523214Uncertain significancesingle nucleotide variantCardiovascular phenotype

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.