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Gene entry

TNFRSF1A

TNF receptor superfamily member 1A

Chromosome
12
Cytoband
12p13.31
Variants (rsID)
13

TNFRSF1A is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 12 (region 12p13.31). Its official name is “TNF receptor superfamily member 1A”. The reference table lists 13 variants (rsID) for this gene.

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Clinically classified variants

10 reference-table entries with clinical significance.

  • rs1800693Benignsingle nucleotide variantMultiple sclerosis, susceptibility to, 5|TNF receptor-associated periodic fever syndrome (TRAPS)|Susceptibility to severe coronavirus disease (COVID-19)|Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR6|Autoinflammatory syndrome
  • rs767455Benignsingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)|Susceptibility to severe coronavirus disease (COVID-19)|Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR7
  • rs104895245Conflicting interpretationssingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)
  • rs104895271Conflicting interpretationssingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)|Inborn genetic diseases|Autoinflammatory syndrome
  • rs200900510Conflicting interpretationssingle nucleotide variantBehcet disease|TNF receptor-associated periodic fever syndrome (TRAPS)|Autoinflammatory syndrome
  • rs104895217Pathogenicsingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)
  • rs104895219Pathogenicsingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)
  • rs104895220Pathogenicsingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)
  • rs104895228Pathogenicsingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)
  • rs4149584Pathogenicsingle nucleotide variantTNF receptor-associated periodic fever syndrome (TRAPS)

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.