Genetics University — Research, Education, Medical Genetics
Knowledge Hub

Gene entry

TNF

tumor necrosis factor

Chromosome
6
Cytoband
6p21.33
Variants (rsID)
15

TNF is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 6 (region 6p21.33). Its official name is “tumor necrosis factor”. The reference table lists 15 variants (rsID) for this gene.

ShareE-MailWhatsAppLinkedInXFacebookTelegram

Clinically classified variants

2 reference-table entries with clinical significance.

  • rs1800629Drug responsesingle nucleotide variantetanercept response - Efficacy|Susceptibility to severe coronavirus disease (COVID-19)|Human immunodeficiency virus dementia, susceptibility to|Psoriatic arthritis, susceptibility to|Migraine without aura, susceptibility to|Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR4|Endometriosis|Systemic lupus erythematosus, susceptibility to|Inherited susceptibility to asthma|Malaria, cerebral, susceptibility to|Septic shock, susceptibility to
  • rs1799724Risk factorsingle nucleotide variantVascular dementia, susceptibility to|Alzheimer disease, susceptibility to

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.