Gene entry
TMPRSS3
transmembrane serine protease 3
- Chromosome
- 21
- Cytoband
- 21q22.3
- Variants (rsID)
- 33
TMPRSS3 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 21 (region 21q22.3). Its official name is “transmembrane serine protease 3”. The reference table lists 33 variants (rsID) for this gene.
Clinically classified variants
19 reference-table entries with clinical significance.
- rs2839500Benignsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs45598239Benignsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs61731564Benignsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs928302Benignsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs111033261Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs113747896Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs114904237Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs146159479Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs185332310Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs186972955Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs374793617Conflicting interpretationssingle nucleotide variantRare genetic deafness|Childhood onset hearing loss|Hearing loss, autosomal recessive|Hearing impairment|Autosomal recessive nonsyndromic hearing loss 8
- rs397517379Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
- rs28939084Likely pathogenicsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8|Ear malformation
- rs372526764Likely pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 8
- rs139805921Pathogenicsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8|Hearing impairment
- rs147231991Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 8|Hearing impairment
- rs181949335Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 8|Hearing impairment
- rs111033537Uncertain significancesingle nucleotide variant
- rs143762350Uncertain significancesingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 8
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.