STK11

Clinically classified variants

88 reference-table entries with clinical significance.

• rs111773256Benignsingle nucleotide variantPeutz-Jeghers syndrome
• rs2075604Benignsingle nucleotide variantSquamous cell lung carcinoma|Peutz-Jeghers syndrome
• rs532889728Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Hereditary breast ovarian cancer syndrome
• rs59912467Benignsingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome|Malignant tumor of breast|Breast and/or ovarian cancer
• rs9282859Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Malignant tumor of breast
• rs1057524439Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome
• rs199681533Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Carcinoma of pancreas
• rs200078204Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Malignant tumor of breast|Melanoma, cutaneous malignant, susceptibility to, 1
• rs368923696Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome|Malignant tumor of breast
• rs370976710Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Malignant tumor of breast|Breast and/or ovarian cancer
• rs372511774Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs537906142Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Carcinoma of colon
• rs547919101Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs549474196Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs587778695Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs587780009Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Breast carcinoma|Malignant tumor of breast|Breast and/or ovarian cancer
• rs587782020Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs730881961Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs755746417Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs759090799Conflicting interpretationsDeletionPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs759284466Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs767565606Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome|Breast and/or ovarian cancer
• rs774072752Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs774100153Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs863224362Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome|Malignant tumor of breast
• rs878853984Conflicting interpretationssingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs1057520018Likely benignsingle nucleotide variantSquamous cell lung carcinoma|Peutz-Jeghers syndrome
• rs200824447Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs752464256Likely benignDeletionHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs786201213Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs786201349Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs1057518830Likely pathogenicMicrosatelliteIntestinal polyposis|Periorbital hyperpigmentation
• rs1057519858Likely pathogenicsingle nucleotide variantNon-small cell lung carcinoma
• rs1057520038Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs1057520039Likely pathogenicsingle nucleotide variantSquamous cell lung carcinoma
• rs1057520041Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs1057520042Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs1064794805Likely pathogenicsingle nucleotide variant
• rs121913316Likely pathogenicsingle nucleotide variantNeoplasm
• rs121913325Likely pathogenicsingle nucleotide variantNeoplasm
• rs727504171Likely pathogenicsingle nucleotide variant
• rs863224448Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs864622488Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs878853247Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs886037926Likely pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs1057517830Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs1057520606Pathogenicsingle nucleotide variant
• rs1060499961PathogenicDeletionPeutz-Jeghers syndrome
• rs121913323Pathogenicsingle nucleotide variantMelanoma, cutaneous malignant, susceptibility to, 1|Neoplasm
• rs121913324Pathogenicsingle nucleotide variantNeoplasm|Hereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs137853075Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs137853076Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs137853078Pathogenicsingle nucleotide variantMalignant tumor of testis|Hereditary cancer-predisposing syndrome
• rs137853079Pathogenicsingle nucleotide variantCarcinoma of pancreas
• rs137853080Pathogenicsingle nucleotide variantMelanoma, cutaneous malignant, susceptibility to, 1
• rs137853081Pathogenicsingle nucleotide variantMelanoma, cutaneous malignant, susceptibility to, 1
• rs137853082Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs137853083Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs137854584Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs397518440PathogenicDeletionPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs397518441PathogenicDuplicationPeutz-Jeghers syndrome
• rs397518442PathogenicDeletionCarcinoma of pancreas|Peutz-Jeghers syndrome
• rs398123405Pathogenicsingle nucleotide variant
• rs398123406Pathogenicsingle nucleotide variant
• rs587776657PathogenicDeletionPeutz-Jeghers syndrome
• rs587776658Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs587776659PathogenicMicrosatellitePeutz-Jeghers syndrome
• rs587776660PathogenicDeletionPeutz-Jeghers syndrome
• rs587776661PathogenicDeletionPeutz-Jeghers syndrome
• rs587781856PathogenicDeletionHereditary cancer-predisposing syndrome
• rs587782018Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs587782424PathogenicMicrosatelliteHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs727504172Pathogenicsingle nucleotide variant
• rs730881959PathogenicDeletionHereditary cancer-predisposing syndrome
• rs730881979Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome
• rs775595174Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs786200991PathogenicDuplication
• rs786203624PathogenicDeletionHereditary cancer-predisposing syndrome
• rs864622707PathogenicDeletionPeutz-Jeghers syndrome
• rs876658584Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs886037859Pathogenicsingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs886039554Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs886041996PathogenicDeletion
• rs1057520040Uncertain significancesingle nucleotide variantPeutz-Jeghers syndrome
• rs121913317Uncertain significancesingle nucleotide variantNeoplasm|Hereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome
• rs367807476Uncertain significancesingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs376280361Uncertain significancesingle nucleotide variantPeutz-Jeghers syndrome|Hereditary cancer-predisposing syndrome
• rs764449808Uncertain significancesingle nucleotide variantSquamous cell lung carcinoma|Hereditary cancer-predisposing syndrome|Peutz-Jeghers syndrome

Other listed variants

• rs741764
• rs3829686
• rs59951593
• rs138334573

Public references

• NCBI Gene
• Ensembl
• ClinVar