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Gene entry

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

Chromosome
2
Cytoband
2p22.1
Variants (rsID)
40

SOS1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 2 (region 2p22.1). Its official name is “SOS Ras/Rac guanine nucleotide exchange factor 1”. The reference table lists 40 variants (rsID) for this gene.

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Clinically classified variants

26 reference-table entries with clinical significance.

  • rs1043793Benignsingle nucleotide variantFibromatosis, gingival, 1|Noonan syndrome 4
  • rs139290271Benignsingle nucleotide variantRASopathy|Noonan syndrome|Noonan syndrome and Noonan-related syndrome
  • rs141390073Benignsingle nucleotide variantNoonan syndrome|RASopathy|Fibromatosis, gingival, 1|Noonan syndrome 4|Noonan syndrome and Noonan-related syndrome
  • rs143962515Benignsingle nucleotide variantFibromatosis, gingival, 1|Noonan syndrome 4|RASopathy|Noonan syndrome and Noonan-related syndrome
  • rs183998234Benignsingle nucleotide variantFibromatosis, gingival, 1|Hypertrophic cardiomyopathy|RASopathy|Noonan syndrome 4
  • rs201982464Benignsingle nucleotide variantNoonan syndrome|RASopathy|Fibromatosis, gingival, 1|Noonan syndrome 4|Noonan syndrome and Noonan-related syndrome
  • rs55980502Benignsingle nucleotide variantNoonan syndrome 4|Fibromatosis, gingival, 1|RASopathy|Noonan syndrome and Noonan-related syndrome
  • rs56219475Benignsingle nucleotide variantRASopathy|Arrhythmogenic right ventricular cardiomyopathy|Noonan syndrome 4|Noonan syndrome and Noonan-related syndrome
  • rs79270739Benignsingle nucleotide variantNoonan syndrome 4|Fibromatosis, gingival, 1
  • rs8192671Benignsingle nucleotide variantRASopathy|Noonan syndrome|Noonan syndrome 4|Fibromatosis, gingival, 1|Noonan syndrome and Noonan-related syndrome
  • rs142094234Conflicting interpretationssingle nucleotide variantNoonan syndrome and Noonan-related syndrome|RASopathy
  • rs202043599Conflicting interpretationssingle nucleotide variantRASopathy|Fibromatosis, gingival, 1|Noonan syndrome 4
  • rs397517177Conflicting interpretationssingle nucleotide variantRASopathy
  • rs587781172Conflicting interpretationssingle nucleotide variantNoonan syndrome|Gingival fibromatosis
  • rs727505093Conflicting interpretationssingle nucleotide variantNoonan syndrome|RASopathy
  • rs730881026Conflicting interpretationssingle nucleotide variantRASopathy|Noonan syndrome and Noonan-related syndrome
  • rs730881034Conflicting interpretationssingle nucleotide variantRASopathy|Fibromatosis, gingival, 1|Noonan syndrome 4
  • rs141594736Likely benignsingle nucleotide variantRASopathy|Noonan syndrome and Noonan-related syndrome
  • rs763337946Likely benignsingle nucleotide variantRASopathy|Noonan syndrome and Noonan-related syndrome
  • rs137852812Pathogenicsingle nucleotide variantNoonan syndrome 4|Noonan syndrome|RASopathy|Noonan syndrome 4|Fibromatosis, gingival, 1
  • rs137852813Pathogenicsingle nucleotide variantNoonan syndrome 4|Noonan syndrome|RASopathy|Noonan syndrome 1
  • rs137852814Pathogenicsingle nucleotide variantNoonan syndrome 4|Noonan syndrome|RASopathy|Noonan syndrome 4|Fibromatosis, gingival, 1
  • rs267607079Pathogenicsingle nucleotide variantNoonan syndrome 4|Noonan syndrome|RASopathy|Noonan syndrome 4|Fibromatosis, gingival, 1|Noonan syndrome and Noonan-related syndrome|Noonan syndrome 1
  • rs267607080Pathogenicsingle nucleotide variantNoonan syndrome 4|Noonan syndrome|RASopathy
  • rs397517146Pathogenicsingle nucleotide variantNoonan syndrome|RASopathy
  • rs397517168Uncertain significancesingle nucleotide variantPrimary familial hypertrophic cardiomyopathy|RASopathy

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.