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Gene entry

SDHA

succinate dehydrogenase complex flavoprotein subunit A

Chromosome
5
Cytoband
5p15.33
Variants (rsID)
16

SDHA is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 5 (region 5p15.33). Its official name is “succinate dehydrogenase complex flavoprotein subunit A”. The reference table lists 16 variants (rsID) for this gene.

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Clinically classified variants

14 reference-table entries with clinical significance.

  • rs142926807Benignsingle nucleotide variantHereditary pheochromocytoma-paraganglioma|Leigh syndrome|Mitochondrial complex II deficiency, nuclear type 1|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Hereditary cancer-predisposing syndrome
  • rs146653693Conflicting interpretationssingle nucleotide variantHereditary pheochromocytoma-paraganglioma|Mitochondrial complex II deficiency, nuclear type 1|Leigh syndrome|Paragangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Hereditary cancer-predisposing syndrome
  • rs200565489Conflicting interpretationssingle nucleotide variantMitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Paragangliomas 5
  • rs370714378Conflicting interpretationssingle nucleotide variantParagangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5
  • rs371735891Conflicting interpretationssingle nucleotide variantParagangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Hereditary cancer-predisposing syndrome
  • rs751633537Conflicting interpretationssingle nucleotide variantParagangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Hereditary pheochromocytoma-paraganglioma|Leigh syndrome|Hereditary cancer-predisposing syndrome
  • rs768276870Conflicting interpretationssingle nucleotide variantParagangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Hereditary cancer-predisposing syndrome
  • rs142441643Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Paragangliomas 5|Carney triad|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Pilocytic astrocytoma|Mitochondrial complex II deficiency, nuclear type 1|Dilated cardiomyopathy 1GG|Paragangliomas 5|Leigh syndrome|Leigh syndrome|Rhabdomyosarcoma|Mitochondrial complex II deficiency, nuclear type 1|Gastrointestinal stromal tumor
  • rs151170408Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Gastrointestinal stromal tumor|Paragangliomas 5
  • rs748089700Pathogenicsingle nucleotide variantParagangliomas 5|Hereditary cancer-predisposing syndrome|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Opsoclonus-myoclonus syndrome
  • rs766667009Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5
  • rs781764920Pathogenicsingle nucleotide variantParagangliomas 5|Hereditary cancer-predisposing syndrome|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5
  • rs181238392Uncertain significancesingle nucleotide variantParagangliomas 5|Mitochondrial complex II deficiency, nuclear type 1|Hereditary cancer-predisposing syndrome|Paragangliomas 5
  • rs182055219Uncertain significancesingle nucleotide variantMitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Dilated cardiomyopathy 1GG|Leigh syndrome|Mitochondrial complex II deficiency, nuclear type 1|Paragangliomas 5|Hereditary cancer-predisposing syndrome

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.