Gene entry
RET
ret proto-oncogene
- Chromosome
- 10
- Cytoband
- 10q11.21
- Variants (rsID)
- 119
RET is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 10 (region 10q11.21). Its official name is “ret proto-oncogene”. The reference table lists 119 variants (rsID) for this gene.
Clinically classified variants
84 reference-table entries with clinical significance.
- rs10900296Benignsingle nucleotide variantMultiple endocrine neoplasia|Hirschsprung Disease, Dominant|Renal hypodysplasia/aplasia 1|Pheochromocytoma
- rs1800858Benignsingle nucleotide variantHirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia, type 2
- rs1800862Benignsingle nucleotide variantMultiple endocrine neoplasia|Hirschsprung disease, susceptibility to, 1|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs2435355Benignsingle nucleotide variantMultiple endocrine neoplasia|Hirschsprung disease, susceptibility to, 1|Pheochromocytoma|Renal hypodysplasia/aplasia 1
- rs2472737Benignsingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs3026785Benignsingle nucleotide variantHirschsprung disease, protection against|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Multiple endocrine neoplasia|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia, type 2a
- rs35118262Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2|Pheochromocytoma|Multiple endocrine neoplasia|Renal hypodysplasia/aplasia 1
- rs56195026Benignsingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a
- rs76397662Benignsingle nucleotide variantCongenital central hypoventilation|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia|Renal hypodysplasia/aplasia 1|Pheochromocytoma
- rs115272158Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs140658743Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome
- rs141679950Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b|Hereditary cancer-predisposing syndrome
- rs142345108Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a
- rs145122337Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Hirschsprung disease, susceptibility to, 1|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs145798106Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Pheochromocytoma|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia|Renal hypodysplasia/aplasia 1|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a|Appendicitis
- rs146838520Conflicting interpretationssingle nucleotide variantMedullary thyroid carcinoma|Multiple endocrine neoplasia, type 2|Renal hypoplasia/aplasia
- rs147219360Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia|Hirschsprung disease, susceptibility to, 1|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Familial medullary thyroid carcinoma
- rs148935214Conflicting interpretationssingle nucleotide variantElevated basal serum calcitonin|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia|Appendicitis
- rs149926238Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple endocrine neoplasia|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia, type 2
- rs17158558Conflicting interpretationssingle nucleotide variantHirschsprung disease, susceptibility to, 1|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia|Familial medullary thyroid carcinoma|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b|Aganglionic megacolon|Multiple endocrine neoplasia, type 2|Malignant tumor of breast|Breast-ovarian cancer, familial, susceptibility to, 1
- rs1799939Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Renal hypodysplasia/aplasia 1|Hirschsprung disease, susceptibility to, 1|Pheochromocytoma|Multiple endocrine neoplasia|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2
- rs192489011Conflicting interpretationssingle nucleotide variantHirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia|Renal hypodysplasia/aplasia 1|Pheochromocytoma|Hereditary cancer-predisposing syndrome|B-lymphoblastic leukemia/lymphoma with hypodiploidy|Multiple endocrine neoplasia, type 2
- rs34682185Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2a|Pheochromocytoma|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia|Renal hypodysplasia/aplasia 1|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2
- rs369579749Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome
- rs370736139Conflicting interpretationssingle nucleotide variantAganglionic megacolon|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome|Familial medullary thyroid carcinoma
- rs377130948Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome
- rs377767416Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a
- rs551159582Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia|Hirschsprung disease, susceptibility to, 1|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Hereditary cancer-predisposing syndrome
- rs55810667Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Multiple endocrine neoplasia|Hirschsprung disease, susceptibility to, 1|Hereditary cancer-predisposing syndrome
- rs576806329Conflicting interpretationssingle nucleotide variantHirschsprung Disease, Dominant|Renal hypodysplasia/aplasia 1|Multiple endocrine neoplasia|Pheochromocytoma|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs587780806Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b
- rs765463636Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b|Renal hypodysplasia/aplasia 1|Multiple endocrine neoplasia|Pheochromocytoma|Hirschsprung disease, susceptibility to, 1|Hereditary cancer-predisposing syndrome
- rs770674650Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome
- rs77711105Conflicting interpretationssingle nucleotide variantMultiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs77724903Conflicting interpretationssingle nucleotide variantFamilial medullary thyroid carcinoma|Pheochromocytoma|Hereditary cancer-predisposing syndrome|Aganglionic megacolon|Hirschsprung disease, susceptibility to, 1|Multiple endocrine neoplasia|Renal hypodysplasia/aplasia 1|Medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia type 4|Multiple endocrine neoplasia, type 1|Multiple endocrine neoplasia, type 2a|Familial cancer of breast|Multiple endocrine neoplasia, type 2
- rs201992974Likely benignsingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome
- rs121913308Likely pathogenicsingle nucleotide variantMedullary thyroid carcinoma
- rs121913309Likely pathogenicDeletionMedullary thyroid carcinoma
- rs121913313Likely pathogenicDeletionMedullary thyroid carcinoma
- rs193922699Likely pathogenicsingle nucleotide variantHirschsprung disease, susceptibility to, 1
- rs377767391Likely pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2|Aganglionic megacolon
- rs377767442Likely pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs76764689Likely pathogenicsingle nucleotide variantHirschsprung disease, susceptibility to, 1|Aganglionic megacolon
- rs794728687Likely pathogenicsingle nucleotide variant
- rs1060500759Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs377767397Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome
- rs377767404Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia type 4|Multiple endocrine neoplasia, type 1|Multiple endocrine neoplasia, type 2b|Medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2
- rs377767405Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs377767412Pathogenicsingle nucleotide variant6 conditions|Multiple endocrine neoplasia, type 2|Hirschsprung disease, susceptibility to, 1
- rs377767434PathogenicDuplicationFamilial medullary thyroid carcinoma
- rs553418132Pathogenicsingle nucleotide variant
- rs74799832Pathogenicsingle nucleotide variantThyroid carcinoma, sporadic medullary|Pheochromocytoma|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a|Medullary thyroid carcinoma|8 conditions|Multiple endocrine neoplasia, type 1|Thyroid tumor|Multiple endocrine neoplasia type 4|Inborn genetic diseases|Familial medullary thyroid carcinoma|Hirschsprung disease, susceptibility to, 1|Hereditary cancer-predisposing syndrome
- rs75076352Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a|Pheochromocytoma|Multiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|Familial medullary thyroid carcinoma|MEN2 phenotype: Unclassified
- rs75234356Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a|Familial medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia type 4|Multiple endocrine neoplasia, type 1|Medullary thyroid carcinoma|Hereditary cancer-predisposing syndrome|MEN2 phenotype: Unclassified
- rs75873440Pathogenicsingle nucleotide variantFamilial medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome
- rs75996173Pathogenicsingle nucleotide variantPheochromocytoma|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome|Neoplasm|Multiple endocrine neoplasia type 4|Multiple endocrine neoplasia, type 1|Medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2
- rs76262710Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2|6 conditions
- rs77558292Pathogenicsingle nucleotide variantFamilial medullary thyroid carcinoma|Aganglionic megacolon|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs77709286Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a|Pheochromocytoma|Multiple endocrine neoplasia type 4|Multiple endocrine neoplasia, type 2b|Thyroid tumor|Multiple endocrine neoplasia, type 1|Multiple endocrine neoplasia, type 2|Medullary thyroid carcinoma|Hereditary cancer-predisposing syndrome
- rs78014899Pathogenicsingle nucleotide variantFamilial medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Neoplasm|Multiple endocrine neoplasia, type 2a|Medullary thyroid carcinoma|Multiple endocrine neoplasia type 4|Multiple endocrine neoplasia, type 1|Hereditary cancer-predisposing syndrome|Hepatocellular carcinoma
- rs78935588Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a
- rs794727130PathogenicDeletion
- rs794728689PathogenicDeletion
- rs794728691PathogenicDeletion
- rs79658334Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a|7 conditions|MEN2 phenotype: Unclassified|Familial medullary thyroid carcinoma
- rs80069458Pathogenicsingle nucleotide variantMultiple endocrine neoplasia, type 2a
- rs886041443PathogenicDuplication
- rs121913312Uncertain significanceDeletionMedullary thyroid carcinoma|Multiple endocrine neoplasia, type 2
- rs1255575160Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2
- rs142318626Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b|Hereditary cancer-predisposing syndrome
- rs143862573Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
- rs145170911Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|7 conditions|Hereditary cancer-predisposing syndrome|6 conditions
- rs193922700Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome
- rs199718928Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|6 conditions|Multiple endocrine neoplasia|Pheochromocytoma|Renal hypodysplasia/aplasia 1|Hirschsprung disease, susceptibility to, 1
- rs200956659Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a|Multiple endocrine neoplasia, type 2b
- rs267607011Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs374461212Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome
- rs377767390Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs377767422Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2a
- rs377767428Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs55846256Uncertain significancesingle nucleotide variantMultiple endocrine neoplasia, type 2
- rs751572082Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Medulloblastoma|Familial medullary thyroid carcinoma
- rs78347871Uncertain significancesingle nucleotide variantFamilial medullary thyroid carcinoma|Multiple endocrine neoplasia, type 2
- rs79853121Uncertain significancesingle nucleotide variantHirschsprung disease, susceptibility to, 1|Aganglionic megacolon|Multiple endocrine neoplasia, type 2b|Multiple endocrine neoplasia, type 2a|Hereditary cancer-predisposing syndrome|Multiple endocrine neoplasia, type 2
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.