Gene entry
PROC
protein C, inactivator of coagulation factors Va and VIIIa
- Chromosome
- 2
- Cytoband
- 2q14.3
- Variants (rsID)
- 12
PROC is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 2 (region 2q14.3). Its official name is “protein C, inactivator of coagulation factors Va and VIIIa”. The reference table lists 12 variants (rsID) for this gene.
Clinically classified variants
9 reference-table entries with clinical significance.
- rs146922325Conflicting interpretationssingle nucleotide variantThrombophilia due to protein C deficiency, autosomal dominant|Reduced protein C activity
- rs151319700Conflicting interpretationssingle nucleotide variantThrombophilia due to protein C deficiency, autosomal dominant
- rs121918160Likely pathogenicsingle nucleotide variantThrombophilia due to protein C deficiency, autosomal dominant
- rs121918143Pathogenicsingle nucleotide variantThrombophilia due to protein C deficiency, autosomal recessive|Thrombophilia due to protein C deficiency, autosomal dominant|Reduced protein C activity
- rs121918150Pathogenicsingle nucleotide variantThrombophilia due to protein C deficiency, autosomal recessive|Thrombophilia due to protein C deficiency, autosomal dominant
- rs121918153Pathogenicsingle nucleotide variantThrombophilia due to protein C deficiency, autosomal dominant|Reduced protein C activity
- rs121918154Pathogenicsingle nucleotide variantThrombophilia due to protein C deficiency, autosomal dominant|Thromboembolism
- rs1799808Not classifiedupstream_gene_variantThrombophilia|Pik3ca-Related Overgrowth Syndrome|Protein C Deficiency|Atherosclerosis Susceptibility
- rs1799809Not classifiedupstream_gene_variantAtherosclerosis Susceptibility|Stroke, Ischemic|Pulmonary Embolism
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.