Gene entry
PRNP
prion protein (Kanno blood group)
- Chromosome
- 20
- Cytoband
- 20p13
- Variants (rsID)
- 9
PRNP is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 20 (region 20p13). Its official name is “prion protein (Kanno blood group)”. The reference table lists 9 variants (rsID) for this gene.
Clinically classified variants
6 reference-table entries with clinical significance.
- rs150351644Benignsingle nucleotide variantInherited prion disease|Huntington disease-like 1
- rs16990018Benignsingle nucleotide variantSpongiform encephalopathy with neuropsychiatric features|Inherited prion disease|Huntington disease-like 1
- rs1799990Benignsingle nucleotide variantAlzheimer disease, early-onset, susceptibility to|Aphasia, primary progressive, susceptibility to|Prion disease, susceptibility to|Inherited prion disease|Huntington disease-like 1|Inherited Creutzfeldt-Jakob disease
- rs1800014Benignsingle nucleotide variantProtection against Creutzfeldt-Jakob disease|Inherited prion disease|Huntington disease-like 1
- rs74315412Likely pathogenicsingle nucleotide variantInherited Creutzfeldt-Jakob disease|Huntington disease-like 1
- rs74315408Pathogenicsingle nucleotide variantInherited Creutzfeldt-Jakob disease|Inherited prion disease|Huntington disease-like 1|Gerstmann-Straussler-Scheinker syndrome
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.