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Gene entry

POLD1

DNA polymerase delta 1, catalytic subunit

Chromosome
19
Cytoband
19q13.33
Variants (rsID)
20

POLD1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 19 (region 19q13.33). Its official name is “DNA polymerase delta 1, catalytic subunit”. The reference table lists 20 variants (rsID) for this gene.

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Clinically classified variants

18 reference-table entries with clinical significance.

  • rs3218772Benignsingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs3218775Benignsingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome|Carcinoma of colon
  • rs56022846Benignsingle nucleotide variantColorectal cancer, susceptibility to, 10
  • rs1057521166Conflicting interpretationssingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs145473716Conflicting interpretationssingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome|Malignant tumor of breast
  • rs147911699Conflicting interpretationssingle nucleotide variantCarcinoma of colon|Colorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome|Familial colorectal cancer|Colorectal cancer, susceptibility to, 10|Mandibular hypoplasia-deafness-progeroid syndrome
  • rs149569984Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Colorectal cancer, susceptibility to, 10
  • rs199545019Conflicting interpretationssingle nucleotide variantColorectal cancer, susceptibility to, 10|Carcinoma of colon|Hereditary cancer-predisposing syndrome
  • rs199993010Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Colorectal cancer, susceptibility to, 10|Carcinoma of colon
  • rs368033860Conflicting interpretationssingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs370478977Conflicting interpretationssingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs770660636Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Colorectal cancer, susceptibility to, 10
  • rs775363857Conflicting interpretationssingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs757406292Likely benignsingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs398122386PathogenicMicrosatelliteMandibular hypoplasia-deafness-progeroid syndrome|Hereditary cancer-predisposing syndrome|Colorectal cancer, susceptibility to, 10
  • rs587777627Pathogenicsingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs201804732Uncertain significancesingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome
  • rs375365167Uncertain significancesingle nucleotide variantColorectal cancer, susceptibility to, 10|Hereditary cancer-predisposing syndrome

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.