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Gene entry

MYO7A

myosin VIIA

Chromosome
11
Cytoband
11q13.5
Variants (rsID)
97

MYO7A is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 11 (region 11q13.5). Its official name is “myosin VIIA”. The reference table lists 97 variants (rsID) for this gene.

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Clinically classified variants

75 reference-table entries with clinical significance.

  • rs1052030Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs11237123Benignsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1B
  • rs12420129Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs139889944Benignsingle nucleotide variantUsher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs56023295Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs77625410Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs948962Benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs111033192Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|MYO7A-Related Disorders|Usher syndrome type 1B
  • rs111033227Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1B
  • rs111033229Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11
  • rs111033252Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Usher syndrome type 1B
  • rs111033287Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs111033416Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs117966637Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1
  • rs142293185Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs150114658Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Usher syndrome type 1B
  • rs184866544Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2
  • rs187165412Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1
  • rs199561332Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs200454015Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1B|Meniere disease
  • rs201539845Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Rare genetic deafness|Usher syndrome type 1B|See cases
  • rs371029653Conflicting interpretationssingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs372493678Conflicting interpretationssingle nucleotide variantRetinal dystrophy|Usher syndrome type 1B
  • rs372535399Conflicting interpretationssingle nucleotide variantNonsyndromic Hearing Loss, Recessive|Retinitis pigmentosa-deafness syndrome|Nonsyndromic Hearing Loss, Dominant|Usher syndrome type 1B
  • rs397516327Conflicting interpretationssingle nucleotide variantUsher syndrome type 1B
  • rs41298131Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2
  • rs41298753Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Usher syndrome type 1B
  • rs45450893Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1B
  • rs60103800Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11
  • rs727505004Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Usher syndrome type 1B
  • rs782607566Conflicting interpretationssingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs868979094Conflicting interpretationssingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2
  • rs35776264Likely benignsingle nucleotide variantNonsyndromic Hearing Loss, Dominant|Nonsyndromic Hearing Loss, Recessive|Retinitis pigmentosa-deafness syndrome
  • rs41298135Likely benignsingle nucleotide variantUsher syndrome type 1B|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome
  • rs45629132Likely benignsingle nucleotide variantAutosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B|Meniere disease|Usher syndrome
  • rs111033181Likely pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Retinal dystrophy|MYO7A-Related Disorders|Usher syndrome
  • rs111033202Likely pathogenicDeletionRare genetic deafness
  • rs111033389Likely pathogenicsingle nucleotide variantRare genetic deafness
  • rs111033426Likely pathogenicsingle nucleotide variantRare genetic deafness|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2
  • rs111033482Likely pathogenicsingle nucleotide variantRare genetic deafness
  • rs111033486Likely pathogenicsingle nucleotide variantUsher syndrome|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Retinal dystrophy|Usher syndrome type 1B
  • rs111033510Likely pathogenicInsertionRare genetic deafness
  • rs377670513Likely pathogenicsingle nucleotide variantRare genetic deafness|Usher syndrome
  • rs111033174Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs111033178Pathogenicsingle nucleotide variantUsher syndrome type 1|Usher syndrome|Inborn genetic diseases|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|MYO7A-Related Disorders|Autosomal recessive nonsyndromic hearing loss 2|Retinal dystrophy|Usher syndrome type 1B
  • rs111033180Pathogenicsingle nucleotide variantUsher syndrome type 1|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Rare genetic deafness|Usher syndrome type 1B
  • rs111033182Pathogenicsingle nucleotide variantRare genetic deafness|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Retinal dystrophy|Autosomal recessive nonsyndromic hearing loss 2
  • rs111033187PathogenicDuplicationUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Rare genetic deafness|Hearing loss, autosomal recessive
  • rs111033198Pathogenicsingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Rare genetic deafness
  • rs111033201Pathogenicsingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Rare genetic deafness|Usher syndrome type 1B
  • rs111033206Pathogenicsingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Rare genetic deafness|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1B
  • rs111033214Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Retinal dystrophy|Autosomal recessive nonsyndromic hearing loss 2|Hearing loss, autosomal recessive|Usher syndrome type 1B
  • rs111033233Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2
  • rs111033238PathogenicDeletionRare genetic deafness
  • rs111033239PathogenicDeletionRare genetic deafness
  • rs111033283Pathogenicsingle nucleotide variantRare genetic deafness|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1B
  • rs111033285Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Retinal dystrophy|Usher syndrome type 1B
  • rs111033290Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1
  • rs111033390PathogenicMicrosatelliteRare genetic deafness
  • rs111033404Pathogenicsingle nucleotide variantRare genetic deafness
  • rs111033433PathogenicDeletionRare genetic deafness
  • rs111033448PathogenicDeletionRare genetic deafness|Hearing loss, autosomal recessive|Autosomal recessive nonsyndromic hearing loss 2
  • rs121965082Pathogenicsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1B
  • rs121965085Pathogenicsingle nucleotide variantUsher syndrome type 1B|Rare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1
  • rs199897298Pathogenicsingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Retinal dystrophy|Hearing loss|Usher syndrome type 1B
  • rs28934610Pathogenicsingle nucleotide variantUsher syndrome type 1B|Rare genetic deafness|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Retinal dystrophy
  • rs369125667Pathogenicsingle nucleotide variantRare genetic deafness
  • rs376764423Pathogenicsingle nucleotide variantUsher syndrome type 1|Retinal dystrophy|MYO7A-Related Disorders|Autosomal recessive nonsyndromic hearing loss 2|Rare genetic deafness|Usher syndrome type 1B
  • rs397516295Pathogenicsingle nucleotide variantUsher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Rare genetic deafness|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1B
  • rs41298133Pathogenicsingle nucleotide variantUsher syndrome type 1B|Rare genetic deafness|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal recessive nonsyndromic hearing loss 2
  • rs878864531Pathogenicsingle nucleotide variantAutosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome type 1|Usher syndrome type 1B
  • rs111033512Uncertain significancesingle nucleotide variantUsher syndrome type 1B
  • rs368341987Uncertain significancesingle nucleotide variantMYO7A-Related Disorders|Autosomal dominant nonsyndromic hearing loss 11|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Autosomal dominant nonsyndromic hearing loss 11|Usher syndrome type 1|Usher syndrome type 1B
  • rs369458838Uncertain significancesingle nucleotide variantRare genetic deafness|Autosomal recessive nonsyndromic hearing loss 2|Usher syndrome type 1|Usher syndrome
  • rs375200566Uncertain significancesingle nucleotide variantUsher syndrome type 1B

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.