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Gene entry

MRE11

MRE11 double strand break repair nuclease

Chromosome
11
Cytoband
11q21
Variants (rsID)
30

MRE11 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 11 (region 11q21). Its official name is “MRE11 double strand break repair nuclease”. The reference table lists 30 variants (rsID) for this gene.

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Clinically classified variants

22 reference-table entries with clinical significance.

  • rs116679717Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder|Hereditary breast ovarian cancer syndrome
  • rs137852760Conflicting interpretationssingle nucleotide variantAtaxia-telangiectasia-like disorder 1|Hereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs137868143Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs139461096Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Depression|Parkinsonism|Dementia|Dystonic disorder|Ataxia-telangiectasia-like disorder
  • rs147771140Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder|Hereditary breast ovarian cancer syndrome|Ataxia-telangiectasia-like disorder 1
  • rs3218740Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs368144567Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs372068015Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs587780138Conflicting interpretationsDeletionHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs587781442Conflicting interpretationsDuplicationHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs587781873Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs61749249Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder|Hereditary breast ovarian cancer syndrome
  • rs766372720Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs774520952Conflicting interpretationssingle nucleotide variantAtaxia-telangiectasia-like disorder 1|Hereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs779269083Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs137852761Pathogenicsingle nucleotide variantAtaxia-telangiectasia-like disorder 1|Hereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs759130031Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs148637964Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder 1|Ataxia-telangiectasia-like disorder
  • rs185439615Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs371077728Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs372000848Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder
  • rs376555330Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Ataxia-telangiectasia-like disorder|Ataxia-telangiectasia-like disorder 1

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.