Gene entry
KCNE2
potassium voltage-gated channel subfamily E regulatory subunit 2
- Chromosome
- 21
- Cytoband
- 21q22.11
- Variants (rsID)
- 12
KCNE2 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 21 (region 21q22.11). Its official name is “potassium voltage-gated channel subfamily E regulatory subunit 2”. The reference table lists 12 variants (rsID) for this gene.
Clinically classified variants
8 reference-table entries with clinical significance.
- rs183427173Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Long QT syndrome 6
- rs199473367Conflicting interpretationssingle nucleotide variantAcquired long QT syndrome|Long QT syndrome 6
- rs2234916Conflicting interpretationssingle nucleotide variantLong QT syndrome, drug-associated|Cardiovascular phenotype|Long QT syndrome|Long QT syndrome 6
- rs74315447Conflicting interpretationssingle nucleotide variantLong QT syndrome 6|Congenital long QT syndrome|KCNE2-Related Disorders|Cardiac arrhythmia
- rs74315448Conflicting interpretationssingle nucleotide variantLong QT syndrome 6|Cardiovascular phenotype|Atrial fibrillation, familial, 4|Cardiac arrhythmia
- rs74315449Conflicting interpretationssingle nucleotide variantAtrial fibrillation, familial, 4|Atrial fibrillation|Long QT syndrome|Primary familial hypertrophic cardiomyopathy|Atrial fibrillation, familial, 4|Long QT syndrome 6|Long QT syndrome 6
- rs148968498Likely benignsingle nucleotide variantCongenital long QT syndrome|Long QT syndrome|Long QT syndrome 6
- rs16991654Pathogenicsingle nucleotide variantLong QT syndrome 3/6, digenic|Congenital long QT syndrome
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.