Gene entry
HRAS
HRas proto-oncogene, GTPase
- Chromosome
- 11
- Cytoband
- 11p15.5
- Variants (rsID)
- 11
HRAS is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 11 (region 11p15.5). Its official name is “HRas proto-oncogene, GTPase”. The reference table lists 11 variants (rsID) for this gene.
Clinically classified variants
10 reference-table entries with clinical significance.
- rs138272051Benignsingle nucleotide variantRASopathy|Costello syndrome|Noonan syndrome|Noonan syndrome and Noonan-related syndrome|Hereditary cancer-predisposing syndrome
- rs397517144Benignsingle nucleotide variantCostello syndrome|RASopathy|6 conditions|Hereditary cancer-predisposing syndrome
- rs369106578Conflicting interpretationssingle nucleotide variantCostello syndrome
- rs121917757Likely pathogenicsingle nucleotide variantCongenital myopathy with excess of muscle spindles|Costello syndrome
- rs121917759Likely pathogenicsingle nucleotide variantCostello syndrome|Neoplasm of the large intestine|Gastric adenocarcinoma|Multiple myeloma|Acute myeloid leukemia|Neoplasm of uterine cervix|Lung adenocarcinoma
- rs104894227Pathogenicsingle nucleotide variantCostello syndrome
- rs121917756Pathogenicsingle nucleotide variantCongenital myopathy with excess of muscle spindles|Costello syndrome
- rs121917758Pathogenicsingle nucleotide variantCostello syndrome
- rs587782949Uncertain significancesingle nucleotide variantSupravalvar aortic stenosis|Pulmonic stenosis|Costello syndrome
- rs727504424Not classifiedsingle nucleotide variant
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.