Gene entry
HCN4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
- Chromosome
- 15
- Cytoband
- 15q24.1
- Variants (rsID)
- 24
HCN4 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 15 (region 15q24.1). Its official name is “hyperpolarization activated cyclic nucleotide gated potassium channel 4”. The reference table lists 24 variants (rsID) for this gene.
Clinically classified variants
12 reference-table entries with clinical significance.
- rs138714806Benignsingle nucleotide variantBrugada syndrome 8|Sick sinus syndrome 2, autosomal dominant|Cardiovascular phenotype
- rs142735148Benignsingle nucleotide variantBrugada syndrome 8|Cardiovascular phenotype|Cardiomyopathy|Sick sinus syndrome 2, autosomal dominant
- rs147181577Benignsingle nucleotide variantBrugada syndrome 8|Cardiovascular phenotype
- rs140354126Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Brugada syndrome 8
- rs148453034Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Brugada syndrome 8|Sick sinus syndrome 2, autosomal dominant
- rs201418838Conflicting interpretationssingle nucleotide variantCardiomyopathy|Brugada syndrome 8
- rs373411041Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Brugada syndrome 8|Sick sinus syndrome 2, autosomal dominant
- rs62641689Conflicting interpretationssingle nucleotide variantSudden cardiac death|Brugada syndrome 8|Sick sinus syndrome 2, autosomal dominant|Cardiovascular phenotype
- rs727503958Conflicting interpretationssingle nucleotide variantCardiovascular phenotype|Brugada syndrome 8
- rs775803239Conflicting interpretationssingle nucleotide variantBrugada syndrome 8
- rs200546024Likely benignsingle nucleotide variantBrugada syndrome 8
- rs786205418Uncertain significanceInsertionBrugada syndrome 8|Ventricular tachycardia
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.