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Gene entry

GCK

glucokinase

Chromosome
7
Cytoband
7p13
Variants (rsID)
81

GCK is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 7 (region 7p13). Its official name is “glucokinase”. The reference table lists 81 variants (rsID) for this gene.

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Clinically classified variants

66 reference-table entries with clinical significance.

  • rs144798843Benignsingle nucleotide variantTransient Neonatal Diabetes, Recessive|Maturity-onset diabetes of the young type 2|Hyperinsulinism due to glucokinase deficiency|Permanent neonatal diabetes mellitus
  • rs142829768Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2|Transient Neonatal Diabetes, Recessive|Permanent neonatal diabetes mellitus|Hyperinsulinism due to glucokinase deficiency
  • rs193922268Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2|Maturity onset diabetes mellitus in young
  • rs193922271Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922301Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922306Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922311Conflicting interpretationssingle nucleotide variant
  • rs193922314Conflicting interpretationsDeletionMaturity-onset diabetes of the young type 2|Maturity onset diabetes mellitus in young
  • rs193922331Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2|Gestational diabetes|Maturity onset diabetes mellitus in young
  • rs193922333Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922337Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs77440690Conflicting interpretationssingle nucleotide variantMaturity-onset diabetes of the young type 2|Permanent neonatal diabetes mellitus|Hyperinsulinism due to glucokinase deficiency|Transient Neonatal Diabetes, Recessive|Type 2 diabetes mellitus
  • rs193922253Likely pathogenicInsertionMaturity-onset diabetes of the young type 2
  • rs193922259Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922260Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922262Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922263Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922266Likely pathogenicsingle nucleotide variantMonogenic diabetes
  • rs193922267Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922269Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922273Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922277Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922278Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922279Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922286Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922290Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922295Likely pathogenicDeletionMaturity-onset diabetes of the young type 2
  • rs193922302Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922303Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922304Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922307Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922308Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922309Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922310Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922312Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922313Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922315Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922316Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922319Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922320Likely pathogenicDeletionMaturity-onset diabetes of the young type 2
  • rs193922322Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922323Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922325Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922327Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922330Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922332Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922336Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922339Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922340Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922341Likely pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs144723656Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs148311934Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2|Maturity-onset diabetes of the young type 2|Type 2 diabetes mellitus|Permanent neonatal diabetes mellitus|Hyperinsulinism due to glucokinase deficiency|Maturity onset diabetes mellitus in young
  • rs193922254PathogenicDeletionMaturity-onset diabetes of the young type 2
  • rs193922265Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922272Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2|Monogenic diabetes
  • rs193922281Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922287Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922289Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2|Monogenic diabetes
  • rs193922297Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922317Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922329Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs193922335Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2|Diabetes mellitus
  • rs193922338Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2
  • rs80356655Pathogenicsingle nucleotide variantMaturity-onset diabetes of the young type 2|Permanent neonatal diabetes mellitus 1
  • rs193922285Uncertain significancesingle nucleotide variantMaturity-onset diabetes of the young type 2|Permanent neonatal diabetes mellitus|Transient Neonatal Diabetes, Recessive|Hyperinsulinism due to glucokinase deficiency
  • rs193922300Uncertain significancesingle nucleotide variant

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.