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Gene entry

FLCN

folliculin

Chromosome
17
Cytoband
17p11.2
Variants (rsID)
45

FLCN is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 17 (region 17p11.2). Its official name is “folliculin”. The reference table lists 45 variants (rsID) for this gene.

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Clinically classified variants

37 reference-table entries with clinical significance.

  • rs116643153Benignsingle nucleotide variantMultiple fibrofolliculomas
  • rs143483053Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas|Familial spontaneous pneumothorax
  • rs3744124Benignsingle nucleotide variantMultiple fibrofolliculomas
  • rs3803761Benignsingle nucleotide variantMultiple fibrofolliculomas|Familial spontaneous pneumothorax
  • rs142934950Conflicting interpretationssingle nucleotide variantMultiple fibrofolliculomas|Colorectal cancer|Hereditary cancer-predisposing syndrome
  • rs150752548Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas
  • rs199643834Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas|Familial spontaneous pneumothorax
  • rs372207262Conflicting interpretationssingle nucleotide variantFamilial spontaneous pneumothorax|Multiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs41419545Conflicting interpretationssingle nucleotide variantCarcinoma of colon|Hereditary cancer-predisposing syndrome|Multiple fibrofolliculomas|Familial spontaneous pneumothorax|Colorectal cancer
  • rs767671406Conflicting interpretationsMicrosatelliteHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas
  • rs78683075Conflicting interpretationssingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome|Colorectal cancer
  • rs878855218Likely pathogenicsingle nucleotide variantMultiple fibrofolliculomas
  • rs137852929Pathogenicsingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome|Familial spontaneous pneumothorax
  • rs398124526PathogenicDuplicationMultiple fibrofolliculomas|Familial spontaneous pneumothorax
  • rs398124528Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas
  • rs398124529PathogenicDeletionMultiple fibrofolliculomas
  • rs398124541PathogenicDeletionMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs398124542PathogenicDuplicationMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome|Familial spontaneous pneumothorax
  • rs750146811PathogenicDeletionFamilial spontaneous pneumothorax|Multiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs755959303Pathogenicsingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs758175953Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas|Multiple fibrofolliculomas|Potocki-Lupski syndrome|Nonpapillary renal cell carcinoma|Familial spontaneous pneumothorax|Carcinoma of colon
  • rs786203218PathogenicMicrosatelliteFamilial spontaneous pneumothorax|Hereditary cancer-predisposing syndrome|Multiple fibrofolliculomas
  • rs864622651PathogenicDeletionMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs876658390PathogenicDeletionHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas
  • rs876658409Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Multiple fibrofolliculomas
  • rs878855213PathogenicDeletionMultiple fibrofolliculomas
  • rs878855217PathogenicDeletionMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs879255667Pathogenicsingle nucleotide variantMultiple fibrofolliculomas
  • rs879255668Pathogenicsingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs879255669PathogenicDuplicationMultiple fibrofolliculomas
  • rs879255677PathogenicDuplicationMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs879255678Pathogenicsingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome|Familial spontaneous pneumothorax|Potocki-Lupski syndrome|Carcinoma of colon|Multiple fibrofolliculomas|Nonpapillary renal cell carcinoma
  • rs879255683Pathogenicsingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs142288285Uncertain significancesingle nucleotide variantMultiple fibrofolliculomas|Familial spontaneous pneumothorax
  • rs148257120Uncertain significancesingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs190786280Uncertain significancesingle nucleotide variantMultiple fibrofolliculomas|Hereditary cancer-predisposing syndrome
  • rs190965235Uncertain significancesingle nucleotide variantMultiple fibrofolliculomas

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.