Gene entry
F2
coagulation factor II, thrombin
- Chromosome
- 11
- Cytoband
- 11p11.2
- Variants (rsID)
- 13
F2 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 11 (region 11p11.2). Its official name is “coagulation factor II, thrombin”. The reference table lists 13 variants (rsID) for this gene.
Clinically classified variants
9 reference-table entries with clinical significance.
- rs3136516Benignsingle nucleotide variantThrombophilia due to thrombin defect
- rs5896Benignsingle nucleotide variantCongenital prothrombin deficiency|Thrombophilia due to thrombin defect
- rs5898Benignsingle nucleotide variantThrombophilia due to thrombin defect|Congenital prothrombin deficiency
- rs143064939Conflicting interpretationssingle nucleotide variantThrombophilia due to thrombin defect|Congenital prothrombin deficiency
- rs1799963Conflicting interpretationssingle nucleotide variantThrombophilia due to thrombin defect|Ischemic stroke|Pregnancy loss, recurrent, susceptibility to, 2|Congenital prothrombin deficiency|Venous thromboembolism|Hereditary factor II deficiency disease|Cerebral palsy
- rs5900Conflicting interpretationssingle nucleotide variantCongenital prothrombin deficiency|Thrombophilia due to thrombin defect
- rs121918477Pathogenicsingle nucleotide variantHereditary factor II deficiency disease
- rs121918478Pathogenicsingle nucleotide variantHereditary factor II deficiency disease
- rs121918485Pathogenicsingle nucleotide variantHereditary factor II deficiency disease
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.