Gene entry
DPYD
dihydropyrimidine dehydrogenase
- Chromosome
- 1
- Cytoband
- 1p21.3
- Variants (rsID)
- 429
DPYD is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 1 (region 1p21.3). Its official name is “dihydropyrimidine dehydrogenase”. The reference table lists 429 variants (rsID) for this gene.
Clinically classified variants
53 reference-table entries with clinical significance.
- rs291592Benignsingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs291593Benignsingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs56160474Benignsingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs56276561Benignsingle nucleotide variant
- rs56293913Benignsingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72728438Benignsingle nucleotide variant
- rs114096998Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs142619737Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs189768576Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs200562975Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs367619008Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs3918289Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs45589337Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs61622928Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72549304Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs777425216Conflicting interpretationssingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs115232898Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|fluorouracil response - Other|fluorouracil response - Toxicity
- rs17376848Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|fluorouracil response - Toxicity|capecitabine response - Toxicity
- rs1801158Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|fluorouracil response - Toxicity|capecitabine response - Toxicity
- rs1801159Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|capecitabine response - Toxicity|fluorouracil response - Toxicity
- rs1801160Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|capecitabine response - Toxicity|fluorouracil response - Other|fluorouracil response - Toxicity
- rs1801265Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|capecitabine response - Toxicity|fluorouracil response - Toxicity
- rs1801266Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|fluorouracil response - Other
- rs1801268Drug responsesingle nucleotide variantfluorouracil response - Other
- rs2297595Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|capecitabine response - Toxicity|fluorouracil response - Toxicity
- rs3918290Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|Fluorouracil response|Hirschsprung disease, susceptibility to, 1|22 conditions|fluorouracil response - Toxicity|fluorouracil response - Other|capecitabine response - Toxicity|tegafur response - Toxicity
- rs55886062Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|fluorouracil response - Other|capecitabine response - Toxicity|tegafur response - Toxicity|fluorouracil response - Toxicity
- rs56038477Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|fluorouracil response - Toxicity|capecitabine response - Toxicity
- rs67376798Drug responsesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency|Fluorouracil response|Inborn genetic diseases|tegafur response - Toxicity|capecitabine response - Toxicity|fluorouracil response - Toxicity|fluorouracil response - Other
- rs72549303Drug responseDeletionfluorouracil response - Other|Dihydropyrimidine dehydrogenase deficiency
- rs75017182Drug responsesingle nucleotide variantcapecitabine response - Toxicity|fluorouracil response - Toxicity|fluorouracil response - Other
- rs199469537Likely benignsingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72549310Likely pathogenicsingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72547602Pathogenicsingle nucleotide variantFluorouracil response
- rs138616379Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs140602333Uncertain significancesingle nucleotide variant
- rs141044036Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs144395748Uncertain significancesingle nucleotide variant
- rs146529561Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs147601618Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs1801267Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs377143350Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs547099198Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs56056384Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72549305Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72549307Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs72975710Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs748639205Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs760663364Uncertain significancesingle nucleotide variantDihydropyrimidine dehydrogenase deficiency
- rs114968502Not classifiedsingle nucleotide variant
- rs115349832Not classifiedsingle nucleotide variant
- rs115632870Not classifiedsingle nucleotide variant
- rs145548112Not classifiedsingle nucleotide variant
Other listed variants
- rs495257
- rs592609
- rs827497
- rs868185
- rs993568
- rs1399289
- rs1577896
- rs1760216
- rs1760217
- rs1812389
- rs1879371
- rs1879372
- rs1879374
- rs1974204
- rs1999571
- rs2027056
- rs2137975
- rs2151562
- rs2152878
- rs2786508
- rs2811174
- rs2811203
- rs3897854
- rs4264037
- rs4350236
- rs4949952
- rs4950025
- rs4970716
- rs4970722
- rs6593634
- rs6593638
- rs6593639
- rs6604094
- rs6668296
- rs6684683
- rs6692946
- rs7517899
- rs7520949
- rs7525922
- rs7526691
- rs7528631
- rs7545340
- rs7545712
- rs7548189
- rs10157336
- rs10158132
- rs10158174
- rs10465748
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.