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Gene entry

DCLRE1C

DNA cross-link repair 1C

Chromosome
10
Cytoband
10p13
Variants (rsID)
23

DCLRE1C is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 10 (region 10p13). Its official name is “DNA cross-link repair 1C”. The reference table lists 23 variants (rsID) for this gene.

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Clinically classified variants

10 reference-table entries with clinical significance.

  • rs12768894Benignsingle nucleotide variantHistiocytic medullary reticulosis|Severe combined immunodeficiency due to DCLRE1C deficiency
  • rs41298896Benignsingle nucleotide variantHistiocytic medullary reticulosis|Severe combined immunodeficiency due to DCLRE1C deficiency|Severe combined immunodeficiency, athabascan-type
  • rs61749163Benignsingle nucleotide variantHistiocytic medullary reticulosis|Severe combined immunodeficiency due to DCLRE1C deficiency
  • rs41297018Conflicting interpretationssingle nucleotide variantSevere combined immunodeficiency due to DCLRE1C deficiency|Histiocytic medullary reticulosis
  • rs121908156Pathogenicsingle nucleotide variantSevere combined immunodeficiency due to DCLRE1C deficiency|Severe combined immunodeficiency due to DCLRE1C deficiency|Histiocytic medullary reticulosis|Histiocytic medullary reticulosis
  • rs121908157Pathogenicsingle nucleotide variantSevere combined immunodeficiency, athabascan-type|Severe combined immunodeficiency due to DCLRE1C deficiency
  • rs115250914Uncertain significancesingle nucleotide variantSevere combined immunodeficiency due to DCLRE1C deficiency|Histiocytic medullary reticulosis
  • rs147013097Uncertain significancesingle nucleotide variantSevere combined immunodeficiency due to DCLRE1C deficiency|Severe combined immunodeficiency, athabascan-type
  • rs182977883Uncertain significancesingle nucleotide variant
  • rs41299658Uncertain significancesingle nucleotide variantHistiocytic medullary reticulosis|Severe combined immunodeficiency due to DCLRE1C deficiency|Severe combined immunodeficiency, athabascan-type

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.