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Gene entry

COMT

catechol-O-methyltransferase

Chromosome
22
Cytoband
22q11.21
Variants (rsID)
27

COMT is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 22 (region 22q11.21). Its official name is “catechol-O-methyltransferase”. The reference table lists 27 variants (rsID) for this gene.

Clinically classified variants

4 reference-table entries with clinical significance.

  • rs4633Benignsingle nucleotide variantTramadol response
  • rs4680Benignsingle nucleotide variantCATECHOL-O-METHYLTRANSFERASE POLYMORPHISM|Tramadol response
  • rs4818Benignsingle nucleotide variantTramadol response
  • rs6267Drug responsesingle nucleotide variantSchizophrenia, susceptibility to|Tramadol response

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.