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Gene entry

CHRNA4

cholinergic receptor nicotinic alpha 4 subunit

Chromosome
20
Cytoband
20q13.33
Variants (rsID)
32

CHRNA4 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 20 (region 20q13.33). Its official name is “cholinergic receptor nicotinic alpha 4 subunit”. The reference table lists 32 variants (rsID) for this gene.

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Clinically classified variants

15 reference-table entries with clinical significance.

  • rs1044396Benignsingle nucleotide variantNicotine addiction, protection against|Seizure|Autosomal dominant nocturnal frontal lobe epilepsy|Autosomal dominant nocturnal frontal lobe epilepsy 1
  • rs2229959Benignsingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy 1|Seizure|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs281865068Benignsingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy 1|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs61737042Benignsingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy|Seizure
  • rs121912243Conflicting interpretationssingle nucleotide variantTobacco use disorder|Inborn genetic diseases|Autosomal dominant nocturnal frontal lobe epilepsy|Amyotrophic lateral sclerosis
  • rs121912282Conflicting interpretationssingle nucleotide variantTobacco use disorder|Autosomal dominant nocturnal frontal lobe epilepsy|Frontotemporal dementia
  • rs121912283Conflicting interpretationssingle nucleotide variantTobacco use disorder|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs144716263Conflicting interpretationssingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy
  • rs146651027Conflicting interpretationssingle nucleotide variantTobacco addiction, susceptibility to|Autosomal dominant nocturnal frontal lobe epilepsy 1|Autosomal dominant nocturnal frontal lobe epilepsy|Seizure|Autosomal dominant nocturnal frontal lobe epilepsy 1
  • rs201123897Conflicting interpretationssingle nucleotide variantSeizure|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs56142348Conflicting interpretationssingle nucleotide variantSeizure|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs56175056Conflicting interpretationssingle nucleotide variantSeizure|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs78306886Conflicting interpretationssingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy|Seizure
  • rs121909580Pathogenicsingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy 1|Autosomal dominant nocturnal frontal lobe epilepsy
  • rs28931591Pathogenicsingle nucleotide variantAutosomal dominant nocturnal frontal lobe epilepsy 1|Autosomal dominant nocturnal frontal lobe epilepsy|Seizure

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.