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Gene entry

CDH1

cadherin 1

Chromosome
16
Cytoband
16q22.1
Variants (rsID)
68

CDH1 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 16 (region 16q22.1). Its official name is “cadherin 1”. The reference table lists 68 variants (rsID) for this gene.

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Clinically classified variants

51 reference-table entries with clinical significance.

  • rs113055163Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs139866691Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Orofacial cleft|Breast and/or ovarian cancer
  • rs142822590Benignsingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome|Neoplasm of stomach|Colon cancer|Malignant tumor of breast|Breast and/or ovarian cancer
  • rs149127230Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Endometrial carcinoma
  • rs16260Benignsingle nucleotide variantProstate cancer, susceptibility to|Hereditary diffuse gastric adenocarcinoma
  • rs200894246Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Malignant tumor of breast|Breast and/or ovarian cancer
  • rs33935154Benignsingle nucleotide variantEndometrial carcinoma|Hereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome|Malignant tumor of breast|Breast and/or ovarian cancer
  • rs35187787Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Breast neoplasm|Breast and/or ovarian cancer|Familial cancer of breast
  • rs35572355Benignsingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome|Neoplasm of stomach|Hereditary breast ovarian cancer syndrome
  • rs368492235Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Malignant tumor of breast|Familial cancer of breast
  • rs370864592Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Hereditary breast ovarian cancer syndrome
  • rs587780117Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast
  • rs587780786Benignsingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs754143182Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs771993728Benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs115418995Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Malignant tumor of breast
  • rs138135866Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs201223411Conflicting interpretationssingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs201637081Conflicting interpretationssingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs34507583Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Hereditary breast ovarian cancer syndrome|Malignant tumor of breast
  • rs373179391Conflicting interpretationssingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs587776399Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs587780118Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast
  • rs587782061Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs587782549Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast
  • rs748086082Conflicting interpretationssingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs750651204Conflicting interpretationssingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs766505270Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Malignant tumor of breast
  • rs781633588Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs786202613Conflicting interpretationssingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs121964871Likely benignsingle nucleotide variantEndometrial carcinoma|Hereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Malignant tumor of breast
  • rs121964872Likely benignsingle nucleotide variantNeoplasm of ovary|Hereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast
  • rs149450874Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Breast and/or ovarian cancer
  • rs199886166Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs200911775Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast|Malignant tumor of breast
  • rs202115589Likely benignsingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs372989292Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Breast and/or ovarian cancer
  • rs587780119Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast
  • rs587782366Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs587782647Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs730881654Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs786201463Likely benignsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs876660771Likely pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs121964877Pathogenicsingle nucleotide variantHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs587780113Pathogenicsingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Hereditary diffuse gastric adenocarcinoma|Familial cancer of breast|Familial cancer of breast
  • rs587781290PathogenicDuplicationHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Breast lobular carcinoma
  • rs587783048PathogenicDeletionHereditary diffuse gastric adenocarcinoma|Hereditary cancer-predisposing syndrome
  • rs786202033PathogenicDeletionHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma|Malignant tumor of breast
  • rs786202151PathogenicDeletionHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma
  • rs864622655PathogenicDeletionHereditary diffuse gastric adenocarcinoma
  • rs587781919Uncertain significancesingle nucleotide variantHereditary cancer-predisposing syndrome|Hereditary diffuse gastric adenocarcinoma

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.