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Gene entry

C3

complement C3

Chromosome
19
Cytoband
19p13.3
Variants (rsID)
23

C3 is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 19 (region 19p13.3). Its official name is “complement C3”. The reference table lists 23 variants (rsID) for this gene.

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Clinically classified variants

9 reference-table entries with clinical significance.

  • rs2230199Benignsingle nucleotide variantMACULAR DEGENERATION, AGE-RELATED, 9, SUSCEPTIBILITY TO|C3S/C3F POLYMORPHISM|Age related macular degeneration 9
  • rs2230204Benignsingle nucleotide variantComplement component 3 deficiency|Atypical hemolytic-uremic syndrome with C3 anomaly|Age related macular degeneration 9
  • rs2230205Benignsingle nucleotide variantAtypical hemolytic-uremic syndrome with C3 anomaly|Age related macular degeneration 9|Complement component 3 deficiency
  • rs2277984Benignsingle nucleotide variantAge related macular degeneration 9|Complement component 3 deficiency|Atypical hemolytic-uremic syndrome with C3 anomaly
  • rs423490Benignsingle nucleotide variantComplement component 3 deficiency|Atypical hemolytic-uremic syndrome with C3 anomaly|Age related macular degeneration 9
  • rs141737564Conflicting interpretationssingle nucleotide variantComplement component 3 deficiency|Age related macular degeneration 9|Atypical hemolytic-uremic syndrome with C3 anomaly
  • rs2230210Conflicting interpretationssingle nucleotide variantAge related macular degeneration 9|Complement component 3 deficiency|Atypical hemolytic-uremic syndrome with C3 anomaly|Atypical hemolytic-uremic syndrome with C3 anomaly|Age related macular degeneration 9|Complement component 3 deficiency
  • rs200918899Uncertain significancesingle nucleotide variantAtypical hemolytic-uremic syndrome with C3 anomaly
  • rs200967589Uncertain significancesingle nucleotide variant

Other listed variants

Public references

Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.