Gene entry
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
- Chromosome
- 2
- Cytoband
- 2q35
- Variants (rsID)
- 20
ATIC is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 2 (region 2q35). Its official name is “5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase”. The reference table lists 20 variants (rsID) for this gene.
Clinically classified variants
4 reference-table entries with clinical significance.
- rs2372536Benignmissense_variantAica-Ribosuria Due to Atic Deficiency|Rheumatoid Arthritis|Arthritis|Juvenile Arthritis|Juvenile Rheumatoid Arthritis|Enthesopathy|Methotrexate Toxicity
- rs121434478Conflicting interpretationssingle nucleotide variantAICA-ribosiduria|Macular dystrophy
- rs4673993Drug responsesingle nucleotide variantmethotrexate response - Efficacy
- rs201429123Uncertain significancesingle nucleotide variantAICA-ribosiduria
Other listed variants
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.