Gene entry
APP
amyloid beta precursor protein
- Chromosome
- 21
- Cytoband
- 21q21.3
- Variants (rsID)
- 66
APP is a protein-coding gene, meaning the body reads it as instructions to build a protein, located on chromosome 21 (region 21q21.3). Its official name is “amyloid beta precursor protein”. The reference table lists 66 variants (rsID) for this gene.
Clinically classified variants
3 reference-table entries with clinical significance.
- rs140304729Benignsingle nucleotide variantVascular dementia|Alzheimer disease
- rs63750066Conflicting interpretationssingle nucleotide variantAlzheimer disease type 1|Alzheimer disease|Primary degenerative dementia of the Alzheimer type, presenile onset|Cerebral amyloid angiopathy, APP-related
- rs63750363Uncertain significancesingle nucleotide variantAlzheimer disease type 1
Other listed variants
- rs3991
- rs128648
- rs214488
- rs216757
- rs364048
- rs373521
- rs380417
- rs383700
- rs454017
- rs462281
- rs466433
- rs1782977
- rs1783024
- rs1981326
- rs2000989
- rs2014146
- rs2026225
- rs2070655
- rs2226332
- rs2829973
- rs2829981
- rs2830006
- rs2830008
- rs2830051
- rs2830076
- rs2830090
- rs2830098
- rs3787634
- rs6516727
- rs7276036
- rs7276845
- rs7279377
- rs7283050
- rs7283060
- rs7283136
- rs9978069
- rs9981258
- rs9982732
- rs17001547
- rs17001660
- rs34322089
- rs36003052
- rs45562444
- rs58908134
- rs62222412
- rs71317448
- rs72635017
- rs73163761
- rs73163773
- rs75804853
- rs77790696
- rs116881101
- rs117079913
- rs117306989
- rs117349040
- rs117476165
- rs117650267
- rs117873188
Public references
Data from the institutional reference table and public NCBI annotation. For education only; not a substitute for medical or genetic counselling.